70396-07-5Relevant academic research and scientific papers
Stereoselective Synthesis of Pyrans from Epoxyalkenes: Dual Catalysis with Palladium and Br?nsted Acid
Setterholm, Noah A.,McDonald, Frank E.
, p. 6259 - 6274 (2018/05/29)
We describe regio- and stereoselective cycloisomerizations of alcohols tethered to epoxyalkenes, to construct alkene-substituted pyrans. These transformations are best catalyzed by Pd(PPh3)4 in the presence of phosphite ligands, and with diphenylphosphinic acid as an essential Br?nsted acid cocatalyst for activation of the epoxyalkene.
