704-16-5

Upstream product

• 108-94-1 cyclohexanone 
• 107-91-5 cyanoacetic acid amide 
• 4354-73-8 2-(cyclohexylidene)malononitrile 
• 6802-76-2 ethyl 2-cyano-2-cyclohexylideneacetate 
• 89809-97-2 2-amino-3,5-dicyano-6-phenyl-4H-pyran-4-spirocyclohexane 

Downstream Products

• 53661-31-7 3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 
• 1130-32-1 3-azaspiro[5.5]undecane-2,4-dione 
• 4815-28-5 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 130089-88-2 Spiropyrimidin-4-thion> 

Relevant academic research and scientific papers

New Options of Multicomponent Condensations Leading to Functional Derivatives of 2-Pyridons

Abstract: Multicomponent condensations of activated olefins, functionalized CH-acids, and alkylating reagents, which open up the possibility of preparing derivatives of substituted 2-pyridones, have been studied. The structure of some compounds has been c

Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles

A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit

Tetrahydro benzothiophene derivative and application thereof to preparation of glycogen synthase kinase 3 beta inhibitor

The invention discloses a tetrahydro benzothiophene derivative and the application thereof to the preparation of a glycogen synthase kinase 3 beta inhibitor. The tetrahydro benzothiophene derivative, pharmaceutically acceptable salt, optical active body or racemate thereof has a chemical structure as shown in a formula I. Experiments show that the compound has good GSK-3 beta inhibitory activity. In addition, the invention further provides a method for preparing a tetrahydro benzothiophene compound. The method is short in synthesis route, simple in preparation process and easy to operate, and can meet the requirements of large-scale industrial production.

Homogeneous and stereoselective copper(II)-catalyzed monohydration of methylenemalononitriles to 2-cyanoacrylamides

A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed. The protocol has proved to be suitable for the monohydration of dicyanobenzenes and 2-substituted malononitriles.

Synthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents

A series of 3-Substituted amino-4,5-tetramethylene thieno[2,3-d] [1,2,3]-triazine-4(3H)-ones have been synthesized and characterized by UV,IR, 1H NMR, elemental and mass spectral analysis. The title compounds were evaluated for their antimicrobial activit

PROCESS FOR PREPARING CYCLOHEXANEDIACETIC ACID MONOAMIDE

A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.

Synthesis of Cyclobutenes by the Novel Photochemical Ring Contraction of 4-Substituted 2-Amino-3,5-dicyao-6-phenyl-4H-pyrans

4-Substituted 2-amino-3,5-dicyano-6-phenyl-4H-pyrans undergo a novel photochemical ring contraction to cyclobutenes from the triplet state.For example, irradiation of a solution of 2-amino-3,5-dicyano-6-phenyl-4H-pyran-4-spirocyclopentane (9a) in methylen

A Novel Photochemical Ring Contraction of 4H-Pyrans. A New Route to Selectively Substituted Cyclobutenes

The novel photochemical ring contraction of some 4H-pyrans to cyclobutenes is described.