1130-32-1

Basic information

• Product Name: 3,3-Pentamethylene glutarimide
• Synonyms: 3-AZASPIRO[4.5]DECAN-2-ONE;4,4-PENTAMETHYLENE-2-PYRROLIDINONE;3,3-Pentamethylene-2-Pyrrolidoinone;3,3-Pentamethylene-2-pyrrolidoinone(CAI) or 3-Azaspiro{5,5} undecane-2,4-dione;3,3-Pentamethylene;3,3-PENTAMETHYLENE GLUTARIMIDE(CAI);3-azaspiro(5,5)undecan-2,4-dione;beta,beta-pentamethylen-glutarsaeureimid
• CAS NO: 1130-32-1
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• EINECS: 214-459-1
• Product Categories: INTERMEDIATESOFGABAPENTIN;(intermediate of gabapentin);Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1130-32-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 84-89 °C(lit.)
• Boiling Point: 362.3 °C at 760 mmHg
• Flash Point: 161.2 °C
• Appearance: /Solid
• Density: 1.14 g/cm³
• Vapor Pressure: 1.96E-05mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 11.71±0.20(Predicted)
• CAS DataBase Reference: 3,3-Pentamethylene glutarimide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-Pentamethylene glutarimide(1130-32-1)
• EPA Substance Registry System: 3,3-Pentamethylene glutarimide(1130-32-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: CM0120000
• Hazardous Substances Data: 1130-32-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Gabapentin intermediate.

InChI:InChI=1/C10H15NO2/c12-8-6-10(7-9(13)11-8)4-2-1-3-5-10/h1-7H2,(H,11,12,13)

Upstream product

• 1010-26-0 1,1-cyclohexanediacetic acid anhydride 
• 108-94-1 cyclohexanone 
• 372-09-8 cyanoacetic acid 
• 4355-11-7 1,1-cyclohexanediacetic acid 
• 77287-34-4 formamide 
• 704-16-5 Cyanocarbamidomethylenecyclohexane 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 60142-96-3 H-Gpn-OH 
• 1125-01-5 3-azaspiro[5.5]undecane hydrochloride 
• 64744-50-9 gabapentin-lactam 
• 180-44-9 3-azaspiro[5.5]undecane 
• 99189-60-3 [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid 

Relevant articles and documents

Simple, improved synthesis of 3-azaspiro[5,5]undecane-2,4-dione, the precursor of gabapentin

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Preparation method of gabapentin intermediate

The invention provides a preparation method of a gabapentin intermediate, and relates to the field of chemical organic synthesis. The preparation method comprises the following steps: taking cyanoacetic acid and cyclohexanone as raw materials, carrying out condensation, hydrolysis and decarboxylation reactions to obtain imide in an intermediate body, and further carrying out alkaline hydrolysis toobtain the intermediate cyclohexyl diacetate monoamide. The preparation method of the gabapentin intermediate provided by the invention has the advantages of readily available raw materials, mild reaction conditions, high safety factor, strong operability, simple process, easiness in industrialization, high product purity and stable quality.

CRYSTALLINE FORMS OF GABAPENTIN AND PROCESS THEREOF

The present invention relates to crystalline forms of gabapentin and processes for preparing the same. The present invention particularly relates to crystalline forms of gabapentin form II and Form IIB. The invention also relates to gabapentin form IA and form IB. The gabapentin forms IA and IB are hydrated forma that contain about 20% of water by weight which corresponds to hemipentahydrate. The present invention also relates to the process for preparing these crystalline forms of gabapentin.