3796-19-8

Basic information

• Product Name: 2-trifluoromethylphenylmagnesium chloride
• Synonyms: 2-trifluoromethylphenylmagnesium chloride
• CAS NO: 3796-19-8
• Molecular Weight: 204.862
• Mol File: 3796-19-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-trifluoromethylphenylmagnesium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-trifluoromethylphenylmagnesium chloride(3796-19-8)
• EPA Substance Registry System: 2-trifluoromethylphenylmagnesium chloride(3796-19-8)

Safety Data

• Hazardous Substances Data: 3796-19-8(Hazardous Substances Data)

Upstream product

• 7439-95-4 magnesium 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 392-83-6 o-trifluoromethylphenyl bromide 

Downstream Products

• 79756-81-3 (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 496788-59-1 3-(methoxycarbonyl)-1-methyl-5-(trichloroacetyl)-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 16185-96-9 1-(2-(trifluoromethyl)phenyl)propan-1-one 
• 395-45-9 o-(trifluoromethyl)styrene 
• 219999-02-7 1-(2-Trifluormethyl-phenyl)-2-brom-aethylen 
• 704-41-6 1-ethynyl-2-(trifluoromethyl)benzene 
• 395-44-8 o-trifluoromethylbenzyl bromide 
• 346-06-5 (2-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

Preparation of Trifluoromethylphenyl Magnesium Halides in the Presence of LiCl and Synthesis of 2′-Trifluoromethyl-Aromatic Ketones

The effect of LiCl-promoted insertion of magnesium turnings into halogenated-trifluoromethylbenzenes for Grignard reagent synthesis was investigated. In the presence of less than 1.0 equiv of LiCl, chloro(trifluoromethyl)benzene Grignard reagents were easily generated. The 2-trifluoromethylphenyl magnesium chloride Grignard reagent was obtained in high yield and 2′-trifluoromethyl-substituted aromatic ketone was synthesized through reaction of the obtained Grignard reagent with a carboxylic anhydride in an 83% yield.

PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES

A process for the production of biphenyl derivatives represented by the general formula (1), which is characterized by comprising reacting the chlorine atom of a benzene derivative represented by the general formula (2) with metallic magnesium to form a Grignard reagent and coupling two molecules of the Grignard reagent with each other in the presence of a catalyst and which is excellent in industrial productivity by virtue of its using inexpensive and easily available raw materials. (1) (2) (wherein A’s are at least one member selected from between trifluoromethyl and fluoro; and n is an integer of 1 to 4)