3796-19-8

Upstream product

• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 7439-95-4 magnesium 

Downstream Products

• 346-06-5 (2-(trifluoromethyl)phenyl)methanol 
• 79756-81-3 (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 16185-96-9 1-(2-(trifluoromethyl)phenyl)propan-1-one 
• 395-45-9 o-(trifluoromethyl)styrene 
• 219999-02-7 1-(2-Trifluormethyl-phenyl)-2-brom-aethylen 
• 704-41-6 1-ethynyl-2-(trifluoromethyl)benzene 
• 395-44-8 o-trifluoromethylbenzyl bromide 
• 496788-59-1 3-(methoxycarbonyl)-1-methyl-5-(trichloroacetyl)-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine 

Relevant academic research and scientific papers

Preparation of Trifluoromethylphenyl Magnesium Halides in the Presence of LiCl and Synthesis of 2′-Trifluoromethyl-Aromatic Ketones

The effect of LiCl-promoted insertion of magnesium turnings into halogenated-trifluoromethylbenzenes for Grignard reagent synthesis was investigated. In the presence of less than 1.0 equiv of LiCl, chloro(trifluoromethyl)benzene Grignard reagents were easily generated. The 2-trifluoromethylphenyl magnesium chloride Grignard reagent was obtained in high yield and 2′-trifluoromethyl-substituted aromatic ketone was synthesized through reaction of the obtained Grignard reagent with a carboxylic anhydride in an 83% yield.

Formation of 2-trifluoromethylphenyl grignard reagent via magnesium-halogen exchange: Process safety evaluation and concentration effect

The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5Mconcentration in THF was determined using an Advanced Reactive System Screening Tool (ARSST). The solution generated by employing Knochel's magnesium-halogen

PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES

A process for the production of biphenyl derivatives represented by the general formula (1), which is characterized by comprising reacting the chlorine atom of a benzene derivative represented by the general formula (2) with metallic magnesium to form a Grignard reagent and coupling two molecules of the Grignard reagent with each other in the presence of a catalyst and which is excellent in industrial productivity by virtue of its using inexpensive and easily available raw materials. (1) (2) (wherein A’s are at least one member selected from between trifluoromethyl and fluoro; and n is an integer of 1 to 4)