70401-29-5

Usage

Uses

Used in Research Applications:
2-METHYL-9-ACRIDINECARBALDEHYDE is used as a reagent in the cleavage assay of rRNA by denaturing gel electrophoresis, a technique employed to study the structure and function of ribosomal RNA.
Used in Pharmaceutical Development:
2-METHYL-9-ACRIDINECARBALDEHYDE is used as a building block in the synthesis of peptide-acridine/acridone conjugates, which have potential applications as anticancer, antiviral, and antiprion drugs. These conjugates leverage the biological activity of acridine derivatives to target and combat various diseases and disorders.

InChI:InChI=1/C15H11NO/c1-10-6-7-15-12(8-10)13(9-17)11-4-2-3-5-14(11)16-15/h2-9H,1H3

Upstream product

• 462-80-6 benzyne 
• 24764-92-9 1,4-bis(p-tolyl)-1,4-diaza-1,3-butadiene 
• 70401-28-4 2,9-dimethylacridine 
• 101298-11-7 N',N'-dimethyl-N-(2-methyl-acridin-9-ylmethylene)-p-phenylenediamine-N-oxide 
• 118-92-3 anthranilic acid 

Relevant academic research and scientific papers

Reaction of diimines and benzyne

The reaction between benzyne and the Schiff bases 1a,b and 15a,b leads to the 1,4-bis(2-substituted acridin-10-yl)benzene 4a,b, the N- phenylarylamines 10a,b and the 10-(4-formylphenyl)-substituted acridines 11a,b (from 1a,b) and the 2-substituted acridine-10-carboxyaldehyde 18a,b (from 15a,b). Cyclohexyl (4-cyclohexyliminomethylbenzylidine)amine 1c reacts with benzyne by an ene-reaction to give cyclohexenyl[(4- cyclohexyliminomethylphenyl)benzylidine]amine 14.

Synthesis of 2-methylcarbamazepine, a new internal standard for chromatographic assays of carbamazepine (Tegretol)

The synthesis of 2-methyl-5H-dibenz[b,f]azepine-5-carboxamide (2-methylcarbamazepine, 2-MCBZ), a promising internal standard for chromatographic assays of the antiepileptic agent carbamazepine is described. N-(p-tolyl)anthranilic acid was utilized as a starting material for the synthesis of a key compound, 2,9-dimethylacridine, which was converted in two steps to 2-methyl-9-hydroxymethylacridan. The acridan, in the presence of polyphosphoric acid, was ring-expanded to form 2-methyl-5H-dibenz[b,f]azepine, this latter compound being converted by conventional reactions to its 5-carbamyl derivative, 2-MCBZ.