70402-10-7Relevant academic research and scientific papers
An Efficient Total Synthesis of Neopatulin
Boukouvalas, John,Maltais, Francois
, p. 5769 - 5770 (1994)
A new, highly efficient synthesis of neopatulin (1) has been achieved through Lewis acid-catalysed aldol reaction of 2-formyl-1,3-dithiane (4) with 2-(tert-butyldimethylsiloxy)-4-furan (5).
Divergent synthesis of the co-isolated mycotoxins longianone, isopatulin, and (Z)-ascladiol via furan oxidation
Lykakis, Ioannis N.,Zaravinos, Ioannis-Panayotis,Raptis, Christos,Stratakis, Manolis
experimental part, p. 6339 - 6342 (2009/12/08)
(Chemical Equation Presented) Longianone and the biosynthetically related mycotoxins isopatulin and (Z)-ascladiol were prepared following a divergent route from a readily available furan diol. The route toward longianone features an unprecedented TBAF-pro
Ylidenebutenolide Mycotoxins. Concise Syntheses of Patulin and Neopatulin from Carbohydrate Precursors
Bennett, Mandy,Gill, G. Byron,Pattenden, Gerald,Shuker, Anthony J.,Stapleton, Alan
, p. 929 - 937 (2007/10/02)
Conversion of arabinose 10 to the protected ketone 13 followed by Wittig condensation to 14, acidcatalysed cyclisation (to lactone 16), dehydration and deprotection provides a brief synthesis of the mycotoxic substance patulin 1, which is produced by Penicillium and Aspergillus spp.In a similar manner, the biogenetic precursor to patulin, neopatulin 8, is synthesized from lyxose 25 via the key intermediates 24, 28 and 30.
