Territrem B (TRB) is a fungal metabolite and mycotoxin originally isolated from Aspergillus terreus, characterized as a potent and irreversible inhibitor of acetylcholinesterase (AChE). It exhibits neurotoxic properties, inducing tremors in mice and has been identified as a potent insecticide.
Used in Pesticide Industry:
Territrem B is used as an insecticide for its potent action via irreversible inhibition of acetylcholinesterase (AChE), leading to a disruption in the nervous system of insects and resulting in their death. Its binding mechanism differs significantly from typical irreversible AChE inhibitors such as neostigmine and organophosphates, making it a valuable alternative in pest control strategies.
Used in Pesticide Industry:
Territrem B is used as an insecticide for its potent action via irreversible inhibition of acetylcholinesterase (AChE), leading to a disruption in the nervous system of insects and resulting in their death. Its binding mechanism differs significantly from typical irreversible AChE inhibitors such as neostigmine and organophosphates, making it a valuable alternative in pest control strategies.
70407-20-4
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Basic information
- Product Name: territrem B
- Synonyms: territrem B;(4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-4,4,6aα,12bα-tetramethyl-9-(3,4,5-trimethoxyphenyl)-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione;TERRITREM B(RG)
- CAS NO:70407-20-4
- Molecular Formula: C29H34O9
- Molecular Weight: 526.579
- EINECS: N/A
- Product Categories: N/A
- Mol File: 70407-20-4.mol
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Chemical Properties
- Melting Point: 200～203℃
- Boiling Point: 693°C at 760 mmHg
- Flash Point: 226.5°C
- Appearance: /
- Density: 1.35g/cm3
- Vapor Pressure: 3.68E-20mmHg at 25°C
- Refractive Index: 1.618
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: territrem B(CAS DataBase Reference)
- NIST Chemistry Reference: territrem B(70407-20-4)
- EPA Substance Registry System: territrem B(70407-20-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 70407-20-4(Hazardous Substances Data)
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Biological Activity
Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.Check Digit Verification of cas no
The CAS Registry Mumber 70407-20-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,4,0 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.Calculate Digit Verification of CAS Registry Number 70407-20:
(7*7)+(6*0)+(5*4)+(4*0)+(3*7)+(2*2)+(1*0)=94
94 % 10 = 4
So 70407-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C29H34O9/c1-25(2)9-8-22(30)27(4)28(25,32)11-10-26(3)29(27,33)15-17-19(38-26)14-18(37-24(17)31)16-12-20(34-5)23(36-7)21(13-16)35-6/h8-9,12-14,32-33H,10-11,15H2,1-7H3/t26-,27+,28-,29-/m1/s1
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territrem B
