70413-91-1Relevant academic research and scientific papers
Ligand-Enabled γ-C(sp3)?H Olefination of Free Carboxylic Acids
Ghiringhelli, Francesca,Ghosh, Kiron Kumar,Mondal, Arup,Uttry, Alexander,Wedi, Philipp,van Gemmeren, Manuel
supporting information, p. 12848 - 12852 (2020/06/25)
We report the ligand-enabled C?H activation/olefination of free carboxylic acids in the γ-position. Through an intramolecular Michael addition, δ-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the γ-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.
Fluorine-containing heterocycles: Xix. * synthesis of fluorine-containing quinazolin-4-ones from 3,1-benzoxazin-4-ones
Laeva,Nosova,Lipunova,Golovchenko,Adonin,Parmon,Charushin
body text, p. 913 - 920 (2010/01/03)
Reactions of fluorine-containing 3,1-benzoxazin-4-ones with ammonium acetate, hydrazine, and heteroaromatic amines gave new 3H-, 3-amino-, and 3-hetarylquinazolin-4-ones, respectively. Differences in the conditions of formation of benzoxazinones from anthranilic acids with different fluorination patterns and in the reactions of fluorinated 3,1-benzoxazinones with nitrogen-centered nucleophiles were revealed. Pleiades Publishing, Ltd., 2009.
