70414-02-7Relevant academic research and scientific papers
Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors
Wang, Zhen,Zhang, Yali,Bartual, Sergio G.,Luo, Jinfeng,Xu, Tingting,Du, Wenting,Xun, Qiuju,Tu, Zhengchao,Brekken, Rolf A.,Ren, Xiaomei,Bullock, Alex N.,Liang, Guang,Lu, Xiaoyun,Ding, Ke
supporting information, p. 327 - 332 (2017/03/17)
Acute lung injury (ALI) is a deadly symptom for serious lung inflammation. Discoidin Domain Receptor 1 (DDR1) is a new potential target for anti-inflammatory drug discovery. A new selective tetrahydroisoquinoline-7-carboxamide based DDR1 inhibitor 7ae was
SMALL-MOLECULE INHIBITORS TARGETING DISCOIDIN DOMAIN RECEPTOR 1 AND USES THEREOF
-
Page/Page column 61, (2016/05/24)
Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing an
Direct ortho iodination of β- and γ-aryl alkylamine derivatives
Barluenga, Jose,Alvarez-Gutierrez, Julia M.,Ballesteros, Alfredo,Gonzalez, Jose M.
, p. 1281 - 1283 (2008/03/27)
Two in one! A trifluoroacetamide protecting group not only masks an amine functionality, but also mimics peptidyl directing effects as a controlling unit in an efficient ortho iodination of a variety of biologically relevant small molecules (see example). (Chemical Equation Presented).
