7042-24-2Relevant academic research and scientific papers
Preparation method of naphthofuran derivative
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Paragraph 0076-0079, (2019/04/17)
The invention discloses a method for efficiently synthesizing a naphthofuran derivative from naphthol and an alpha-haloketone under the action of titanium tetrachloride by one step. The method specifically includes adding the naphthol and polyfluoroalcoho
One-step regioselective synthesis of benzofurans from phenols and α-Haloketones
Wang, Bingqiao,Zhang, Qiu,Luo, Juan,Gan, Zongjie,Jiang, Wengao,Tang, Qiang
, (2019/06/21)
Reported here is the direct synthesis of naphthofurans and benzofurans from readily available phenols and α-haloketones promoted by titanium tetrachloride which combines Friedel-Crafts-like alkylation and intramolecular cyclodehydration into one step. This simple protocol allows for the formation of a variety of high value naphthofurans and benzofurans within which a series of cyclic and acyclic groups are readily incorporated. This process demonstrates the advantages of high levels of regioselectivity, broad substrate scope, and moderate to excellent yields.
Titanium tetrachloride promoted cyclodehydration of aryloxyketones: Facile synthesis of benzofurans and naphthofurans with high regioselectivity
Zhang, Qiu,Luo, Juan,Wang, Bingqiao,Xiao, Xiaoqin,Gan, Zongjie,Tang, Qiang
, p. 1337 - 1340 (2019/04/16)
An efficient and facile method for the synthesis of a broad series of benzofurans and naphthofurans is described. The direct intramolecular cyclodehydration of aryloxyketones in the presence of titanium tetrachloride affords the corresponding benzofurans and naphthofurans with good regioselectivity and yields.
Method for synthesizing naphthofuran derivative by taking titanium tetrachloride as dehydrating agent
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Paragraph 0052-0055, (2019/04/17)
The invention discloses a method for preparing a naphthofuran derivative by taking naphthoxy ketone as a raw material through dehydrating cyclization under the action of titanium tetrachloride. Namely, under protection of inert gas, alpha-naphthoxy ketone
Diversified Synthesis of Furans by Coupling between Enols/1,3-Dicarbonyl Compounds and Nitroolefins: Direct Access to Dioxa[5]helicenes
Ghosh, Monoranjan,Santra, Sougata,Mondal, Pallab,Kundu, Dhiman,Hajra, Alakananda
, p. 2525 - 2536 (2015/10/29)
A versatile method for the diversified synthesis of furans and arenofurans has been developed that proceeds through K2CO3-promoted cyclization between enols/1,3-dicarbonyl compounds and nitroolefins at reflux in EtOH. This facile method has been successfully employed in the synthesis of benzotrifuran derivatives, which are useful hole-transporting materials. This procedure also provides direct access to dioxa[5]helicenes. This reaction offers a broad substrate scope, uses an inexpensive base and environmentally benign solvent, and is operationally simple.
