8,9,10,11-Tetrahydrobenzo[b]naphtho[1,2-d]furan

Base Information

• Chemical Name: 8,9,10,11-Tetrahydrobenzo[b]naphtho[1,2-d]furan
• CAS No.: 7042-24-2
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.287
• NSC Number: 32089
• DSSTox Substance ID: DTXSID30990627
• Nikkaji Number: J1.554.596H
• Wikidata: Q82980161
• Mol file: 7042-24-2.mol

Synonyms:8,9,10,11-tetrahydrobenzo[b]naphtho[1,2-d]furan;7042-24-2;NSC32089;DTXSID30990627;NSC-32089

Chemical Property of 8,9,10,11-Tetrahydrobenzo[b]naphtho[1,2-d]furan

Chemical Property:

• Vapor Pressure: 9.19E-06mmHg at 25°C
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 222.104465066
• Heavy Atom Count: 17
• Complexity: 287

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC2=C(C1)C3=C(O2)C=CC4=CC=CC=C43

Technology Process of 8,9,10,11-Tetrahydrobenzo[b]naphtho[1,2-d]furan

There total 4 articles about 8,9,10,11-Tetrahydrobenzo[b]naphtho[1,2-d]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

β-naphthol (135-19-3) + 2-Chlorocyclohexanone (822-87-7) → 8,9,10,11-tetrahydronaphtho[2,1-b]benzofuran (7042-24-2)

Guidance literature:

With titanium tetrachloride; In 2,2,2-trifluoroethanol; Inert atmosphere; Reflux;

Reference yield: 86.0%

1-nitrocyclohexene (2562-37-0) + β-naphthol (135-19-3) → 8,9,10,11-tetrahydronaphtho[2,1-b]benzofuran (7042-24-2)

Guidance literature:

With potassium carbonate; In ethanol; at 80 - 85 ℃; for 6h;

DOI:10.1002/asia.201500710

Reference yield: 78.0%

2-(naphthalen-2-yloxy)cyclohexanone → 8,9,10,11-tetrahydronaphtho[2,1-b]benzofuran (7042-24-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 0.5h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.04.020

upstream raw materials:

1-nitrocyclohexene

β-naphthol

2-Chlorocyclohexanone