70430-20-5Relevant academic research and scientific papers
Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related orphan receptor-α
Doebelin, Christelle,He, Yuanjun,Campbell, Sean,Nuhant, Philippe,Kumar, Naresh,Koenig, Marcel,Garcia-Ordonez, Ruben,Chang, Mi Ra,Roush, William R.,Lin, Li,Kahn, Susan,Cameron, Michael D.,Griffin, Patrick R.,Solt, Laura A.,Kamenecka, Theodore M.
, p. 676 - 684 (2019/10/28)
Background: Despite a massive industry endeavor to develop RORγ-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORα for similar indications. This may be due to the misconception that RORα is
Novel hexafluoroisopropanol derivatives
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Page/Page column 12, (2008/06/13)
The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. The
Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β
Panday, Narendra,Benz, Joerg,Blum-Kaelin, Denise,Bourgeaux, Vanessa,Dehmlow, Henrietta,Hartman, Peter,Kuhn, Bernd,Ratni, Hassen,Warot, Xavier,Wright, Matthew B.
, p. 5231 - 5237 (2007/10/03)
A series of branched and unbranched anilinohexafluoroisopropanols related to the known sulfonamide T0901317 were prepared and evaluated as activators/modulators of both LXRα and LXRβ. A structure-activity relationship was established and compounds with high potency on both the receptors were identified. Many compounds showed a tendency toward selectivity for LXRβ versus LXRα. Several analogues were evaluated for effects on plasma lipoprotein levels in mice. A few of these significantly raised HDL-cholesterol levels in plasma but showed markedly different effects on liver triglyceride content, suggesting that this series may yield candidates with improved efficacy/safety profiles compared to existing molecules.
