70434-30-9

Upstream product

• 70120-16-0 1-bromo-2-benzyloxy-4-(1,1-dimethylheptyl)benzene 
• 70120-09-1 2-(3-benzyloxyphenyl)-2-methylpropionaldehyde 
• 70120-08-0 2-<3-(benzyloxy)phenyl>-2-methylpropionitrile 
• 70120-10-4 1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene 
• 21406-61-1 pentyltriphenylphosphonium bromide 
• 70120-14-8 2-(4-bromo-3-hydroxyphenyl)-2-methyloctane 
• 70120-12-6 2-(3-hydroxyphenyl)-2-methyloctane 
• 930-68-7 cyclohexenone 
• 70434-13-8 3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanone 

Downstream Products

• 70435-47-1 3-[2-Acetoxy-4-(1,1-dimethylheptyl)phenyl]-cyclohexanone 

Relevant academic research and scientific papers

A Cannabinoid Derived Prototypical Analgesic

The synthesis and analgesic testing of 3-cyclohexanol (1) are described.Prior (SAR) studies led us to conclude that the pyran ring of 9-nor-9β-hydroxyhexahydrocannabinol (HHC) was not necessary for the expression of biological activity in this series of cannabinoids.Analysis of models and the use of molecular mechanics calculations suggested that a simpler compound, such as 1, would possess the biological activity of HHC.Compound 1 was prepared in nine steps from acetonitrile (2).Biological testing in five models of pain shows that compound 1 and morphine are equally potent as analgesics and demonstrates that the pyran ring of HHC is not necessary for biological activity.Further simplification of 1 was pursued by the synthesis of 4--2-pentanol (17), but this derivative exhibits significantly reduced analgesic activity.

3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents

Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.