70437-05-7Relevant academic research and scientific papers
A Garratt-Braverman cyclization route towards the synthesis of phenanthridine derivatives and their DNA-binding studies
Mandal, Arundhoti,Bhattacharya, Prabuddha,Das, Amit K.,Basak, Amit
, p. 1975 - 1987 (2019/02/24)
Garratt-Braverman cyclization has been employed to synthesize a series of dihydroisofuran fused phenanthridine derivatives. The established protocol proposes a simpler synthetic alternative to have access to these therapeutically relevant cytotoxic scaffo
Novel selective PPARδ agonists: Optimization of activity by modification of alkynylallylic moiety
Havranek, Miroslav,Sauerberg, Per,Mogensen, John P.,Kratina, Pavel,Jeppesen, Claus B.,Pettersson, Ingrid,Pihera, Pavel
, p. 4144 - 4149 (2008/03/11)
Y-shaped molecules bearing alkynylallylic moieties were found to be potent and selective PPARδ activators. The alkynylallylic moiety was synthesized from alkyn-1-ols by hydroalumination followed by a cross-coupling reaction. Series of active compounds 6 w
Acyclic diaminocarbenes: Simple, versatile ligands for cross-coupling reactions
Dhudshia, Bhartesh,Thadani, Avinash N.
, p. 668 - 670 (2008/02/10)
Acyclic diaminocarbenes are found to be useful ligands for palladium catalyzed Suzuki-Miyaura, Sonogashira and Heck cross-coupling reactions of aryl/alkenyl bromides and chlorides. The Royal Society of Chemistry 2006.
Preparation of quinoline-substituted carbonate and carbamate derivatives
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, (2008/06/13)
The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: Synthesis and structure-activity relationships
Glase, Shelly A.,Akunne, Hyacinth C.,Heffner, Thomas G.,Jaen, Juan C.,MacKenzie, Robert G.,Meltzer, Leonard T.,Pugsley, Thomas A.,Smith, Sarah J.,Wise, Lawrence D.
, p. 3179 - 3187 (2007/10/03)
A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6- tetrahydropyridines with dopaminergic activity is described. The structure- activity relationships of this series were studied by synthesis of analogs and evaluation of their affinities for the dopamine (DA) D2 receptor and inhibition of locomotor activity (LMA) in rodents. The basic amine, alkyne chain length, and aryl groups were varied. Compounds having a 4-phenyl- 1,2,3,6-tetrahydropyridine and an aryl group with hydrogen-bonding substituents separated by a butynyl chain were found to have the most potent dopaminergic activity. Several compounds that were found to have exceptional in vivo activity in LMA inhibition in rodents were evaluated for additional pharmacological activity including binding affinities for other DA receptor subtypes as well as effects on brain DA synthesis, DA neuronal firing, and conditioned avoidance responding in squirrel monkeys.
