70450-22-5

Upstream product

• 27311-64-4 4-Hydroxy-1-methylisoquinoline 
• 70449-94-4 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine 
• 100-44-7 benzyl chloride 
• 176962-15-5 N-Benzyl-5-methyl-11-oxo-5H-dibenzocyclohepten-5,10-imine 
• 100-39-0 benzyl bromide 
• 176962-16-6 C₂₅H₂₃NS₂ 

Downstream Products

• 70449-94-4 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine 

Relevant academic research and scientific papers

Benzyne addition to N-alkyl-4-hydroxy-1-methylisoquinolinium salts; a new and convenient synthesis of (±)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5,10-imine (MK801)

Addition of benzyne, generated by three different methods, to N-benzyl-4-hydroxy-1-methylisoquinolinium betaine provides N-benzyl-5-methyl-11-oxo-5H-dibenzo[a,d] cyclohepten-5,10-imine which can be converted to MK801.

5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof

5-Substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anticonvulsants.