70452-31-2

Upstream product

• 608-05-9 5-methyl-indole-2,3-dione 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 1132-40-7 2-hydroxyimino-N-p-tolyl-acetamide 
• 70452-20-9 3-hydroxy-5-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 106-49-0 p-toluidine 
• 98-86-2 acetophenone 

Downstream Products

• 1181824-23-6 C₃₃H₂₂N₂O₂ 
• 1417157-93-7 5-methyl-2'-phenyl-1,3,1',5',6',7'-hexahydro-3,3'-biindolyl-2,4'-dione 
• 1585206-39-8 ethyl (Z)-3-(5-methyl-2-oxoindolin-3-ylidene)-4-oxo-4-phenylbutanoate 
• 1585206-49-0 ethyl (E)-3-(5-methyl-2-oxoindolin-3-ylidene)-4-oxo-4-phenylbutanoate 

Relevant academic research and scientific papers

Eco-friendly Polyethylene Glycol-400 as a Rapid and Efficient Recyclable Reaction Medium for the Synthesis of Anticancer Isatin-linked Chalcones and Their 3-Hydroxy Precursor

Isatin chalcones and their 3-hydroxy precursors are shown to possess potential anticancer activity and are also versatile substrates and key intermediates for the synthesis of a large variety of bioactive spiro-oxindoles. An environmental friendly tandem

Access to 3-Prenylated Oxindoles by α-Regioselective Prenylation: Application to the Synthesis of (±)-Debromoflustramine e

The development of a rapid, highly efficient, and one-pot synthesis of C3-α-prenylated oxindoles with simple reagents is described. The process is based on zinc-mediated α-regioselective prenylation of 3-acylidene-oxindole with commercially available pren

Squaramide-Catalyzed Enantioselective Cascade Approach to Bispirooxindoles with Multiple Stereocenters

A bifunctional squaramide-catalyzed Michael/Michael cascade reaction for the construction of spirotetrahydrofuran bispirooxindoles was developed. The products were obtained in moderate to excellent yields with excellent diastereo- and enantioselectivities

Synthesis, spectroscopic characterization, and in vitro antimicrobial potency of sulfur-bonded complexes of boron(III)

The present article describes the synthesis and characterization of tetracoordinated boron (III) complexes with monobasic bidentate ligands (L 1H, L2H, L3H, L4H, L5H, and L6H) having the ge

Preparation, characterization and antimicrobial properties of some palladium and platinum complexes with active Schiff base ligands

The synthetic, spectroscopic and biological studies of some palladium and platinum complexes derived from 5-methyl-1,3-dihydro-3-[2-(phenyl)ethylidene]- 2H-indol-2-one-hydrazinecarbothioamide(L1H) and 5-methyl-1,3-dihydro- 3-[2-(phenyl)ethylidene]-2H-indol-2-one-hydrazinecarboxamide(L2H) are reported here. These complexes have been characterized on the basis of elemental analysis, molecular weight determinations and spectral studies including IR, 1H NMR and electronic spectra. The resulting coloured products are monomeric in nature. On the basis of the above studies, square planar geometry has been proposed for the resulting complexes. Both the ligands and their complexes have been screened for their fungicidal and bactericidal activities and the results indicate that they exhibit significant antimicrobial properties.

Facile One Pot Microwave Induced Synthesis of Spiro [indole-pyrazoles] and Spiro [indol-isoxazoles]

The potential of domestic microwave oven has been utilized in an elegant one step synthesis of a series of new fluorine containing spiro [indole-pyrazoles] and spiro [indol-isoxazoles] in 85-95% yields. Results were compared with those obtained following

ORGANOPHOSPHORUS CHEMISTRY, 27. THE REACTION OF ISATIN, 5-METHYLISATIN AND THEIR MONOXIMES WITH ALKYL PHOSPHITES, TRIPHENYLPHOSPHINE AND PHOSPHORUS YLIDES

5-Methylisatin (1b) reacts with TAP (4a-c) and/or DAP (3a-c) to give the respective dialkyl α-hydroxyphosphonates (8a-c).Isatin-monoxime (5a) and 5-methyl isatin-monoxime (5b) react with alkyl phosphites to give dialkyl 2-oxo-indolyl phosphonates (8a-c, 12a-f, 15a-c) as major products.The carbonyl-group at position - 3 in 1b is deoxygenated by triphenylphosphine to give a new phosphorus ylide (17) and by methylenetriphenylphosphoranes (Wittig-reagents, 7a-c) to afford the respective 3-substituted methylenes (19a-c) in good yields.Possible reaction mechanisms were considered and structural assignments were based upon analytical, chemical and spectroscopic (IR, 1H NMR, 31P NMR and MS) results. Key words: Isatins, isatinmonoximes, phosphorylation, triphenylphsophine, Wittig-reaction.