70452-60-7

Upstream product

• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 118-41-2 Eudesmic acid 
• 6178-44-5 ethyl 3,4,5-trimethoxybenzoate 
• 3291-03-0 3,4,5-trimethoxybenzohydrazide 
• 70452-42-5 C₁₈H₂₁N₃O₅S 
• 70452-51-6 5?(3,4,5?trimethoxyphenyl)?4?(4?methoxyphenyl)?4H?1,2,4?triazole?3?thiol 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues

Thirty-two novel 3-alkylsulfanyl-1,2,4-triazole derivatives, designed as cis-restricted combretastatin A-4 analogues, were synthesized and evaluated for their antiproliferative activities. The results indicated that analogue 20 showed more potent antiproliferative activities against PC-3?cell lines than positive control CA-4. Particularly, the most promising compound 25 displayed 5-fold improvement compared to CA-4 in inhibiting HCT116?cell proliferation with IC50values of 1.15?μM. Further flow-activated cell sorting analysis revealed that compound 20 displayed a significant effect on G2/M cell-cycle arrest in a dose-dependent manner in PC-3?cells. From this study, analogues 20 and 25 were the most potent anti-cancer agents in this structural class, and were considered lead compounds for further development as anti-cancer drugs.