70454-02-3Relevant academic research and scientific papers
Microwave-mediated synthesis of 3-unsubstituted β-lactams with aqueous trimethylborane
Yadav, Ram Naresh,Banik, Indrani,Banik, Bimal Krishna
, p. 1381 - 1384 (2020/06/27)
A new microwave-induced method for the preparation of 3-unsubstituted β-lactams is explored via aqueous trimethylborane-mediated reaction of the corresponding xanthates.
Synthesis of β-lactams from acetic acids and imines induced by phenyl dichlorophosphate reagent
Arrieta,Cossio,Palomo
, p. 1703 - 1712 (2007/10/02)
The development of a practical method for the preparation of vinylamino-β-lactams from Dane salts and Schiff bases is described. Among the reagents known to produce β-lactams from imines and acetic acids, only phenyl dichlorophosphate and 1-methyl-2-chloropyridinium iodide are suitable for the synthesis of vinylamino-β-lactams. Reaction of acetic acids with ethanolimine derivatives promoted by phenyl dichlorophosphate affords oxazolidines instead of β-lactams. Protection of the hydroxyl group as the trimethylsilyl ether in the starting Schiff bases provides a convenient route to the corresponding β-lactams instead of oxazolidines. Some observations on the scope of the method are made.
