13831-30-6

Basic information

• Product Name: Acetoxyacetic acid
• Synonyms: ACETOXYACETIC ACID;2-ACETOXY ACETIC ACID;(Acetyloxy)acetic acid;2-Hydroxyacetic acid acetata;Acetylglycolic acid;alpha-Acetoxyacetic acid;Glycolic acid, acetate;O-Acetylglycolic acid
• CAS NO: 13831-30-6
• Molecular Formula: C₄H₆O₄
• Molecular Weight: 118.09
• EINECS: 237-541-9
• Product Categories: C1 to C5;Carbonyl Compounds;Carboxylic Acids
• Mol File: 13831-30-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 67-69 °C(lit.)
• Boiling Point: 141-142 °C12 mm Hg(lit.)
• Flash Point: 103.108 °C
• Appearance: /
• Density: 1.0887 (rough estimate)
• Vapor Pressure: 0.00345mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.69±0.10(Predicted)
• CAS DataBase Reference: Acetoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Acetoxyacetic acid(13831-30-6)
• EPA Substance Registry System: Acetoxyacetic acid(13831-30-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 13831-30-6(Hazardous Substances Data)

Usage

Uses

Acetoxyacetic acid was used in preparation of tert-butyl glycolate.

General Description

Acetoxyacetic acid is kinetically stable degradation product of oxidative degradation of 1,3-dialkylimidazolium ionic liquids in hydrogen peroxide/aceticacid aqueous medium assisted by ultrasonic chemical irradiation. It is an intermediate formed during reactions of manganic acetate in glacial acetic acid with benzene (100°C), chlorobenzene, or toluene.

InChI:InChI=1/C4H6O4/c1-3(5)8-2-4(6)7/h2H2,1H3,(H,6,7)

Upstream product

• 855233-81-7 3,4-diacetoxy-2-methyl-but-2-ene 
• 623-50-7 ethyl 2-hydroxyacetate 
• 64-19-7 acetic acid 
• 89534-50-9 glycolic acid isobutyl ester 
• 37160-61-5 sec-butyl glycolate 
• 87327-59-1 acetoxyacetic acid acetic acid-anhydride 
• 127-09-3 sodium acetate 
• 105-39-5 chloroacetic acid ethyl ester 
• 79-14-1 glycolic Acid 
• 75-36-5 acetyl chloride 
• 109752-08-1 non-2-yn-1-yl acetate 
• 108-24-7 acetic anhydride 
• 627-09-8 Propargyl acetate 
• 96-35-5 glycolic acid methyl ester 

Downstream Products

• 112403-31-3 Acetic acid (3R,4R)-1-(4-methoxy-phenyl)-2-oxo-4-p-tolyl-azetidin-3-yl ester 
• 70454-02-3 Acetic acid (2R,3S)-2-(4-methoxy-phenyl)-4-oxo-1-p-tolyl-azetidin-3-yl ester 
• 50-00-0 formaldehyd 
• 84785-16-0 Essigsaeure-(diacetylamino)methylester 
• 84785-15-9 Acetoxyessigsaeure-acetoxymethylester 
• 84785-17-1 Essigsaeure-methylester 
• 79-14-1 glycolic Acid 
• 171416-09-4 Ac-Gca-pNA 
• 131968-76-8 (+/-)-(3R,4S)-3-acetoxy-N-(4-methoxyphenyl)-4-phenylazetidin-2-one 
• 900184-24-9 (R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate 

Relevant articles and documents

METHOD FOR PRODUCING CYCLIC ESTER

In a method for producing a cyclic ester according to an embodiment of the present invention, a mixture (I) containing an aliphatic polyester, a specific polyalkylene glycol diether, and a sulfonic acid compound as a thermal stabilizer is prepared and heated in predetermined conditions to obtain a mixture (II) in a state of solution. Furthermore, heating of the mixture (II) is continued to distill, together with the polyalkylene glycol diether, a cyclic ester formed by the depolymerization reaction, and thus a distillate (III) is obtained. The cyclic ester is recovered from the distillate (III). At this time, a specific solubilizing agent is added to at least one of the mixture (I) or (II). In this production method, the sulfonic acid compound as the thermal stabilizer is contained in the mixtures (I) and (II) and the distillate (III).

CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.

Ruthenium-Catalyzed Oxidative Cleavage of Alkynes to Carboxylic Acids

We describe an efficient method for the oxidative cleavage of alkynes to carboxylic acids using a combination of RuO2/Oxone/NaHCO3 in a CH3CN/H2O/EtOAc solvent system. Both internal and terminal alkynes, regardless of their electron density, can be oxidized to carboxylic acids in excellent yield (up to 99%). 1H NMR spectroscopy and ESI-MS experiments provided evidence for α-diketones and anhydrides as possible intermediates in these oxidation reactions.