70457-82-8

Upstream product

• 69497-44-5 p-chlorophenyl N-phenylphosphoramidochloridate 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 50-89-5 thymidine 

Downstream Products

• 76742-69-3 thymidine 3'-p-chlorophenyl phosphoranilidate 
• 76742-73-9 C₅₈H₅₅Cl₂N₅O₁₅P₂ 
• 76742-74-0 C₃₈H₃₉Cl₂N₅O₁₄P₂ 

Relevant academic research and scientific papers

2'-DEOXYRIBONUCLEOSIDE 3'-ARYL PHOSPHORANILIDATES KEY INTERMEDIATES IN THE STEREOSPECIFIC SYNTHESIS OF 2'-DEOXYRIBONUCLEOSIDE CYCLIC 3',5'-PHOSPHOROTHIOATES AND DINUCLEOSIDE(3'->5')-PHOSPHOROTHIOATES

Phosphorylation of the 5'-O-monomethoxytrityl-2'-deoxyribonucleosides by means of aryl phosphoranilidochloridates gives the diastereomers of 5'-O-monomethoxytrityl-2'-deoxyribonucleoside 3'-aryl phosphoranilidates.Their separation can be performed by mean

SYNTHESIS OF DEOXYRIBOOLIGONUCLEOTIDES BY USING AROMATIC PHOSPHORAMIDATES AS THE PROTECTING GROUP FOR THE 3'-PHOSPHO ENDS

p-Chlorophenyl phosphoranilidochloridate was used to phosphorylate the 3'-hydroxyl groups of N,5'-O-protected deoxyribonucleotides.These nucleotides served as the 3'-terminal unit in the syntheses of some protected oligonucleotides which were used in a bl