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705-19-1 Usage


2-(2-METHYL-4-NITRO-IMIDAZOL-1-YL)-ETHANOL, also known as Isometronidazole, is an impurity of Metronidazole, a chemotherapeutic agent used for treating Clostridium difficile infections. It is a hypoxic cell sensitizer in humans and mice, which means it enhances the effectiveness of certain cancer treatments by making hypoxic cells more susceptible to the action of these treatments.


Used in Pharmaceutical Industry:
2-(2-METHYL-4-NITRO-IMIDAZOL-1-YL)-ETHANOL is used as a hypoxic cell sensitizer for enhancing the effectiveness of cancer treatments in humans and mice. It is particularly useful in targeting hypoxic cells, which are often resistant to traditional cancer therapies.
Used in Clostridium difficile Treatment:
2-(2-METHYL-4-NITRO-IMIDAZOL-1-YL)-ETHANOL is used as an impurity in Metronidazole, a chemotherapeutic agent that serves as a first line defense against Clostridium difficile infections. Its presence in Metronidazole contributes to the overall effectiveness of the treatment against this harmful bacteria.

Check Digit Verification of cas no

The CAS Registry Mumber 705-19-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 705-19:
61 % 10 = 1
So 705-19-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 2-(2-methyl-4-nitroimidazol-1-yl)ethanol

1.2 Other means of identification

Product number -
Other names R.P. 8979

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:705-19-1 SDS

705-19-1Relevant articles and documents

Crystal Habit Modification of Metronidazole by Supramolecular Gels with Complementary Functionality

Jayabhavan, Sreejith Sudhakaran,Steed, Jonathan W.,Damodaran, Krishna K.

, p. 5383 - 5393 (2021/08/23)

A series of bis(urea) compounds with complementary functional groups similar to the pharmaceutical drug metronidazole and a structural isomer isometronidazole have been synthesized. The gelation properties of these compounds were studied in various solvent/solvent mixtures. The mechanical strength of the isomeric gelators was compared using rheology, and the morphologies of the xerogels were analyzed by scanning electron microscopy. These gels were used as media for metronidazole crystallization resulting in a marked habit modification of the metronidazole crystals in the drug-mimicking gels. However, crystallization in the nonmimetic isomeric gel resulted in morphologies similar to the solution state. These results indicate that the drug-mimetic gels interact with the surface of the drug crystal giving rise to new morphologies.

Solid-liquid phase-transfer catalytic method for N-alkylation of nitroimidazole


, p. 2611 - 2615 (2007/10/02)

A variety of 1-alkyl-2-methyl-4-nitroimidazoles have been synthesized with a solid-liquid phase-transfer catalytic method in excellent yields.

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