705-24-8

Usage

Uses

4,6-Dichloro-2-trifluoromethylpyrimidine

InChI:InChI=1/C5HCl2F3N2/c6-2-1-3(7)12-4(11-2)5(8,9)10/h1H

Upstream product

• 672-47-9 2-trifluoromethyl-4,6-dihydroxypyrimidine 

Downstream Products

• 866648-53-5 6-chloro-N,N-dimethyl-2-(trifluoromethyl)pyrimidin-4-amine 
• 672-46-8 2-(trifluoromethyl)pyrimidine-4,6-diamine 
• 1480-66-6 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine 
• 1582-25-8 4-chloro-6-methyl-2-(trifluoromethyl)pyrimidine 
• 1595145-00-8 (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide 
• 1189444-94-7 4-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)morpholine 
• 24903-69-3 4-methoxy-2-trifluoromethylpyrimidine 
• 1514-96-1 4-chloro-2-(trifluoromethyl)pyrimidine 
• 1546-80-1 2-trifluoromethyl-4-hydroxypyrimidine 
• 1595145-44-0 4-(4-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}phenyl)cyclohexane-1-carboxylic acid 
• 1595145-37-1 4-(4-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}phenyl)benzoic acid 
• 1595145-31-5 4-(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)-2-methoxybenzoic acid 
• 1595145-22-4 4-[(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]benzoic acid 
• 1595145-20-2 (S)-2-(4-((1-(6-(2-((4-cyanophenylethyl)carbamoyl)azetidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)piperidin-4-yl)oxy)phenyl)acetic acid 

Relevant academic research and scientific papers

Preparation method of 4-chloro-2-trifluoromethyl pyrimidine

The invention discloses a preparation method of 4-chloro-2-trifluoromethyl pyrimidine (formula I). According to the preparation method, cheap and easily purchased methyl trifluoroacetate and malonamide are taken as the raw materials. The preparation method has the advantages that no pricy material is used, the reaction conditions are mild, the used equipment is simple, the EHS risk is little, the cost is low, and the preparation method is suitable for massive production.

PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF

The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson’s disease, epilepsy, and addiction.

Pesticidal pyrimidine compounds

Compounds of formula (I) in which X1 and X2 each represents oxygen; S(O)n, n being 0, 1 or 2; or CO, CH2 or NR, R being hydrogen or alkyl; R1 and R10 are each hydrogen or halogen; R2 and R9 are each hydrogen, halogen, cyano, nitro, alkyl, halo-alkyl, alkoxy, alkylthio, amino, mono- or di-alkylamino, alkoxyalkyl, haloalkoxyalkyl or alkoxycarbonyl; R3 and R8 are each hydrogen, chlorine, alkyl, haloalkyl, haloalkenyl, halo-alkynyl, haloalkoxy, haloalkoxycarbenyl, haloalkylthio, haloalkoxyalkyl, haloalkylsulphinyl, or haloalkylsulphonyl, nitro or cyano; R4 and R7 are each hydrogen, halogen, alkyl or alkoxy; R5 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulphonyl or phenyl; and R6 is hydrogen or, when R5 is hydrogen, alkyl; provided that either each phenyl is unsubstituted or at least one of R3 and R8 is not hydrogen, have useful pesticidal activity.

Process for large-scale production of BMY 21502

An improved process, suitable for adaption to large-scale manufacture for synthesis of the cerebral function enhancing agent BMY 21502.