705-24-8

Basic information

• Product Name: 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+%
• Synonyms: 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+%;PyriMidine,4,6-dichloro-2-(trifluoroMethyl)-
• CAS NO: 705-24-8
• Molecular Formula: C₅HCl₂F₃N₂
• Molecular Weight: 216.98
• Product Categories: Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Pyrimidines;Fluorine series
• Mol File: 705-24-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 50-52℃/5mm
• Flash Point: >110°C
• Appearance: /
• Density: 1.585g/mLat 25℃
• Vapor Pressure: 3.63mmHg at 25°C
• Refractive Index: n20/D 1.468
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -7.59±0.30(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+%(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+%(705-24-8)
• EPA Substance Registry System: 4,6-DICHLORO-2-TRIFLUOROMETHYLPYRIMIDINE, 95+%(705-24-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2922
• WGK Germany: 3
• HazardClass: IRRITANT, AVOID SKIN CONTACT
• PackingGroup: Ⅱ
• Hazardous Substances Data: 705-24-8(Hazardous Substances Data)

Usage

Uses

4,6-Dichloro-2-trifluoromethylpyrimidine

InChI:InChI=1/C5HCl2F3N2/c6-2-1-3(7)12-4(11-2)5(8,9)10/h1H

Upstream product

• 672-47-9 2-trifluoromethyl-4,6-dihydroxypyrimidine 

Downstream Products

• 672-46-8 2-(trifluoromethyl)pyrimidine-4,6-diamine 
• 1480-66-6 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine 
• 1595145-00-8 (S)-1-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)-N-(4-cyanophenylethyl)azetidine-2-carboxamide 
• 1189444-94-7 4-(6-chloro-2-(trifluoromethyl)pyrimidin-4-yl)morpholine 
• 24903-69-3 4-methoxy-2-trifluoromethylpyrimidine 
• 1514-96-1 4-chloro-2-(trifluoromethyl)pyrimidine 
• 1546-80-1 2-trifluoromethyl-4-hydroxypyrimidine 
• 1595145-44-0 4-(4-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}phenyl)cyclohexane-1-carboxylic acid 
• 1595145-37-1 4-(4-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}phenyl)benzoic acid 
• 1595145-31-5 4-(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)-2-methoxybenzoic acid 
• 1595145-22-4 4-[(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]benzoic acid 
• 1595145-20-2 (S)-2-(4-((1-(6-(2-((4-cyanophenylethyl)carbamoyl)azetidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)piperidin-4-yl)oxy)phenyl)acetic acid 
• 1595145-19-9 2-{4-[(1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]phenyl}acetic acid 

Relevant articles and documents

Preparation method of 4-chloro-2-trifluoromethyl pyrimidine

The invention discloses a preparation method of 4-chloro-2-trifluoromethyl pyrimidine (formula I). According to the preparation method, cheap and easily purchased methyl trifluoroacetate and malonamide are taken as the raw materials. The preparation method has the advantages that no pricy material is used, the reaction conditions are mild, the used equipment is simple, the EHS risk is little, the cost is low, and the preparation method is suitable for massive production.

Pesticidal pyrimidine compounds

Compounds of formula (I) in which X1 and X2 each represents oxygen; S(O)n, n being 0, 1 or 2; or CO, CH2 or NR, R being hydrogen or alkyl; R1 and R10 are each hydrogen or halogen; R2 and R9 are each hydrogen, halogen, cyano, nitro, alkyl, halo-alkyl, alkoxy, alkylthio, amino, mono- or di-alkylamino, alkoxyalkyl, haloalkoxyalkyl or alkoxycarbonyl; R3 and R8 are each hydrogen, chlorine, alkyl, haloalkyl, haloalkenyl, halo-alkynyl, haloalkoxy, haloalkoxycarbenyl, haloalkylthio, haloalkoxyalkyl, haloalkylsulphinyl, or haloalkylsulphonyl, nitro or cyano; R4 and R7 are each hydrogen, halogen, alkyl or alkoxy; R5 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulphonyl or phenyl; and R6 is hydrogen or, when R5 is hydrogen, alkyl; provided that either each phenyl is unsubstituted or at least one of R3 and R8 is not hydrogen, have useful pesticidal activity.