70522-14-4

Upstream product

• 78-94-4 methyl vinyl ketone 
• 70779-52-1 2-allyl-5,5-ethylenedioxy-2-(3',4'-dimethoxyphenyl)cyclohexanone 
• 20802-16-8 1-(3,4-dimethoxyphenyl)cyclopropanecarbaldehyde 
• 100-46-9 benzylamine 
• 70779-53-2 (1R*,2S*)-2-allyl-5,5-ethylenedioxy-2-(3',4'-dimethoxyphenyl)cyclohexyl acetate 
• 114047-03-9 2-allyl-5,5-ethylenedioxy-2-(3',4'-dimethoxyphenyl)cyclohexanol 
• 70779-54-3 (1R*,2S*)-5,5-ethylenedioxy-2-formylmethyl-2-(3',4'-dimethoxyphenyl)cyclohexyl acetate 
• 88023-67-0 3-oxopent-4-enoic acid tert-butyl ester 
• 144692-22-8 1-Benzyl-3a-(3,4-dimethoxy-phenyl)-1,2,3,3a,4,5-hexahydro-indol-6-one 

Downstream Products

• 70522-15-5 (3aS*,6R*,7aS*)-1-benzyl-3a,4,5,6,7,7a-hexahydro-6-hydroxy-3a-(3',4'-dimethoxyphenyl)indoline 
• 70522-15-5 (3aS*,6S*,7aS*)-1-benzyl-3a,4,5,6,7,7a-hexahydro-6-hydroxy-3a-(3',4'-dimethoxyphenyl)indoline 

Relevant academic research and scientific papers

Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)

The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

SUBSTITUTED UREA-OCTAHYDROINDOLS AS ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 1 (MCH1R)

The invention relates to compounds of the general formula (I). (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, and X are as defined in the description, or pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

Formal syntheses of (±)-mesembrine and (±)-dihydromaritidine

Condensation of 3-arylated Δ1-pyrrolinium salts with t-butyl 3-oxopent-4-enoate 3 followed by treatment with trifluoroacetic acid yielded the alkaloid Δ7-mesembrenone 1 and its N-benzyl analogue 10. These compounds are intermediates

Synthesis of Sceletium and Amaryllidaceae Alkaloids, (+/-)-Mesembrine and (+/-)-Dihydromaritidine, (+/-)-Epidihydromaritidine, (+/-)-Elwesine, and (+/-)-Epielwesine

The alkylation of 2-arylcyclohexanones (12b and 6) with alkyl halides or acrylonitrile and 50percent aq. sodium hydroxide in the presence of a phase-transfer catalyst (18-crown-6) was found to give readily 2-alkyl-2-arylcyclohexanones (14 and 16) in fair