705255-07-8Relevant academic research and scientific papers
Functionalization of Guanosine and 2′-Deoxyguanosine at C6: A Modified Appel Process and SNAr Displacement of Imidazole
Janeba, Zlatko,Lin, Xiaoyu,Robins, Morris J.
, p. 137 - 147 (2007/10/03)
Treatment of sugar-protected 2-N-trityl derivatives of guanosine and 2′-deoxyguanosine with imidazole/triphenylphosphine/iodine/ethyldiisopropylamine gives the corresponding 6-(imidazol-1-yl)-2-(tritylamino)purine nucleosides. S NAr displacement of the imidazole moiety with nucleophiles provides 2-amino-6-substituted-purine nucleosides and 2′-deoxynucleosides.
