83061-20-5 Usage
Composition
Modified nucleoside containing a guanine base with a dimethylamino group attached to the 6-position.
Biological Research
Commonly used as a fluorescent probe for studying nucleic acid structure and function.
Base-pairing Properties
Chemical modification can alter the base-pairing properties and stability of DNA and RNA.
Applications
Biological Research: Studying nucleic acid behavior in different environments.
Therapeutic Development: Potential applications in developing new therapeutic agents for treating genetic disorders and cancer.
Significance
Advancing Understanding: Crucial role in advancing understanding of nucleic acid biology.
Biomedical Research: Promising implications for biomedical research and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 83061-20-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,0,6 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83061-20:
(7*8)+(6*3)+(5*0)+(4*6)+(3*1)+(2*2)+(1*0)=105
105 % 10 = 5
So 83061-20-5 is a valid CAS Registry Number.
83061-20-5Relevant articles and documents
Functionalization of Guanosine and 2′-Deoxyguanosine at C6: A Modified Appel Process and SNAr Displacement of Imidazole
Janeba, Zlatko,Lin, Xiaoyu,Robins, Morris J.
, p. 137 - 147 (2007/10/03)
Treatment of sugar-protected 2-N-trityl derivatives of guanosine and 2′-deoxyguanosine with imidazole/triphenylphosphine/iodine/ethyldiisopropylamine gives the corresponding 6-(imidazol-1-yl)-2-(tritylamino)purine nucleosides. S NAr displacement of the imidazole moiety with nucleophiles provides 2-amino-6-substituted-purine nucleosides and 2′-deoxynucleosides.
