677702-22-6

Basic information

• Product Name: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 1H-Indazole-3-carboxaldehyde,5-iodo-;5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-IODO-3-(1H)INDAZOLE CARBOXALDEHYDE;5-IODO-3-(1H)INDAZOLE CARBOXYLIC ACID;5-Iodo-3-(1H)indazolecarboxyaldehyde;5-IODOINDAZOLE-3-CARBOXYALDEHYDE;5-Iodo-1H-indazole-3-carbaldehyde
• CAS NO: 677702-22-6
• Molecular Formula: C8H5IN2O2
• Molecular Weight: 288.04
• Mol File: 677702-22-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 435.6°C at 760 mmHg
• Flash Point: 217.2°C
• Appearance: /
• Density: 2.111g/cm³
• Vapor Pressure: 8.66E-08mmHg at 25°C
• Refractive Index: 1.824
• Storage Temp.: 2-8°C
• PKA: 10.91±0.40(Predicted)
• CAS DataBase Reference: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID(677702-22-6)
• EPA Substance Registry System: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID(677702-22-6)

Safety Data

• Hazardous Substances Data: 677702-22-6(Hazardous Substances Data)

Usage

General Description

5-Iodo-1H-indazole-3-carboxylic acid is a chemical compound that belongs to the class of indazole derivatives. It is a carboxylic acid compound containing a 5-iodo-1H-indazole core structure with a carboxylic acid functional group at the 3-position. 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID has potential applications in medicinal chemistry as it exhibits various biological activities, including antiviral, antifungal, and antimicrobial properties. It can also be utilized as a starting material for the synthesis of other indazole-based compounds. Additionally, 5-Iodo-1H-indazole-3-carboxylic acid is used as a reagent in organic synthesis for the preparation of pharmaceuticals and agrochemicals.

InChI:InChI=1/C8H5IN2O/c9-5-1-2-7-6(3-5)8(4-12)11-10-7/h1-4H,(H,10,11)

Upstream product

• 16066-91-4 5-iodo-1H-indole 
• 351457-14-2 5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide 
• 705264-87-5 3-hydroxymethyl-5-iodo-1H-indazole 

Relevant articles and documents

An optimized procedure for direct access to 1: H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.

DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS

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PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.