705286-07-3Relevant academic research and scientific papers
SAR by MS: Discovery of a new class of RNA-binding small molecules for the hepatitis C virus: Internal ribosome entry site IIA subdomain
Seth, Punit P.,Miyaji, Alycia,Jefferson, Elizabeth A.,Sannes-Lowery, Kristin A.,Osgood, Stephen A.,Propp, Stephanie S.,Ranken, Ray,Massire, Christian,Sampath, Rangarajan,Ecker, David J.,Swayze, Eric E.,Griffey, Richard H.
, p. 7099 - 7102 (2007/10/03)
A new class of small molecules that bind the HCV RNA IRES IIA subdomain with sub-micromolar affinity is reported. The benzimidazole 'hit' 1 with a KD -100 μM to a 29-mer RNA model of Domain IIA was identified from a 180000-member library using mass spectr
Benzimidazoles and analogs thereof as antivirals
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Page/Page column 22-23, (2010/02/11)
Provided are compounds of the formula: wherein RN1 is a substituent of formula G1-NX1X2, wherein G1 is an optionally further substituted alkylene, which optionally forms, together with RN2,
