705286-08-4Relevant academic research and scientific papers
Benzimidazoles and Methods of Using Same
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, (2021/03/19)
The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus,
SAR by MS: Discovery of a new class of RNA-binding small molecules for the hepatitis C virus: Internal ribosome entry site IIA subdomain
Seth, Punit P.,Miyaji, Alycia,Jefferson, Elizabeth A.,Sannes-Lowery, Kristin A.,Osgood, Stephen A.,Propp, Stephanie S.,Ranken, Ray,Massire, Christian,Sampath, Rangarajan,Ecker, David J.,Swayze, Eric E.,Griffey, Richard H.
, p. 7099 - 7102 (2007/10/03)
A new class of small molecules that bind the HCV RNA IRES IIA subdomain with sub-micromolar affinity is reported. The benzimidazole 'hit' 1 with a KD -100 μM to a 29-mer RNA model of Domain IIA was identified from a 180000-member library using mass spectr
