70529-38-3Relevant academic research and scientific papers
Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
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, (2008/06/13)
2,4,5-Trisubstituted thiazoles of the formula STR1 in which each of R1 and R2, independently of the other, represents an aryl or optionally N-oxidized heteroaryl radical each of which is unsubstituted or substituted by aliphatic hydr
Synthesis and Platelet Aggregation Inhibitory Activity of 4,5-Bis(aryl)-2-substituted-thiazoles
Rynbrandt, Ronald H.,Nishizawa, Edward E.,Balogoyen, Doris P.,Mendoza, A. Rene,Annis, Kathleen A.
, p. 1507 - 1510 (2007/10/02)
In our continuing effort to discover compounds which inhibit collagen-induced platelet aggregation, we have screened compounds in a mouse pulmonary thromboembolism screen.Methyl 4,5-bis(4-methoxyphenyl)-2-thiazoleacetate (3) was very active in the above screen.However, 3 was active for less than 5 min when given orally to guinea pigs.As a result, our synthetic goal was to prepare 2-substituted thiazoles with a much longer duration of activity.This paper describes the preparation of a number 4,5-bis(aryl)-2-substituted-thiazoles and their in vitro and ex vivo activity against collagen-induced platelet aggregation.It was determined that 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole (16) is the most promising compound.
The Synthesis of 2-(5-Phenylthiazol-4-yl)benzoic Acids
Teitei, Tsutomu
, p. 605 - 611 (2007/10/02)
The four-step synthesis of 2-(5-phenylthiazol-4-yl)benzoic acid (2a), and its 2-amino derivatives (2b), required for testing as potential plant growth regulators, is described.The α-bromo ketone (9b) was conveniently prepared from commercially available 3
