705293-89-6

Basic information

• Product Name: 2-ethoxy-1-(2,4-dihydroxy-phenyl)-ethanone
• Synonyms: 2-ethoxy-1-(2,4-dihydroxy-phenyl)-ethanone
• CAS NO: 705293-89-6
• Molecular Weight: 196.203
• Mol File: 705293-89-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-ethoxy-1-(2,4-dihydroxy-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethoxy-1-(2,4-dihydroxy-phenyl)-ethanone(705293-89-6)
• EPA Substance Registry System: 2-ethoxy-1-(2,4-dihydroxy-phenyl)-ethanone(705293-89-6)

Safety Data

• Hazardous Substances Data: 705293-89-6(Hazardous Substances Data)

Upstream product

• 57941-81-8 ethoxy-acetic acid phenyl ester 
• 108-46-3 recorcinol 
• 62957-60-2 2-ethoxyacetonitrile 

Downstream Products

• 705296-96-4 3,7-diethoxy-2-(3,4-diethoxy-phenyl)-chromen-4-one 
• 34811-99-9 ω-Ethoxy-2-hydroxy-4-methoxy-acetophenon 
• 705296-94-2 3-ethoxy-2-(3,4-diethoxy-phenyl)-7-hydroxy-chromen-4-one 

Relevant articles and documents

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors

The biocatalytic Friedel-Crafts acylation has been identified recently for the acetylation of resorcinol using activated acetic acid esters for the synthesis of acetophenone derivatives catalyzed by an acyltransferase. Because the wild-type enzyme is limited to acetic and propionic derivatives as the substrate, variants were designed to extend the substrate scope of this enzyme. By rational protein engineering, the key residue in the active site was identified which can be replaced to allow binding of bulkier acyl moieties. The single-point variant F148V enabled the transformation of previously inaccessible medium chain length alkyl and alkoxyalkyl carboxylic esters as donor substrates with up to 99% conversion and up to >99% isolated yield.