70538-46-4Relevant academic research and scientific papers
Synthesis of?compounds with antiproliferative activity as?analogues of?prenylated natural products existing in?Brazilian propolis
Pisco, Laura,Kordian, Marcus,Peseke, Klaus,Feist, Holger,Michalik, Dirk,Estrada, Ernesto,Carvalho, Jo?o,Hamilton, Gerhard,Rando, Daniela,Quincoces, Jose
, p. 401 - 407 (2006)
This work describes the syntheses and antitumoral properties of five prenyl compounds from which antiproliferative activities were predicted by using the TOPS-MODE approach, a computational method for drug design. The syntheses of 2-(3-methylbut-2-enyloxy
Synthesis of benzofused cyclobutaoxepanones: Via intramolecular annulation of o -cinnamyl chalcones
Chang, Meng-Yang,Tsai, Min-Chen
, p. 2254 - 2268 (2021/03/26)
Intramolecular stereoselective annulation of o-cinnamyloxy chalcones provides two kinds of tricyclic benzofused cyclobutaoxepanones via the synthesized routes of DABCO/NBS (1,4-diazabicyclo[2.2.2]octane/N-bromosuccinimide)-mediated Baylis-Hillman type cyc
AuCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis
Wang, Rui,Chen, Yi,Shu, Mao,Zhao, Wenwen,Tao, Maoling,Du, Chao,Fu, Xiaoya,Li, Ao,Lin, Zhihua
supporting information, p. 1941 - 1946 (2020/02/11)
Compared with the ripeness of olefin metathesis, exploration of the construction of carbon–carbon double bonds through the catalytic carbonyl–olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl3-catalyzed intramolecular ring-closing carbonyl–olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes, polycycles, benzocarbocycles, and N-heterocycle derivatives in good to excellent yields.
Design, Synthesis, and Structure–Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor γ Agonists
Du, Guoxin,Zhao, Yuanyuan,Feng, Li,Yang, Zhuo,Shi, Jiye,Huang, Cheng,Li, Bo,Guo, Fujiang,Zhu, Weiliang,Li, Yiming
, p. 183 - 193 (2017/02/05)
Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been used for the treatment of diabetes with the effect of lowering blood glucose levels and improving insulin sensitivity. Natural compounds such as flavones, flavanones, and isoflavones
A domino synthetic approach for new, angular pyrazol- and isoxazol-heterocycles using [DBU][Ac] as an effective reaction medium
Sutariya, Tushar R.,Labana, Balvantsingh M.,Parmar, Bhagyashri D.,Parmar, Narsidas J.,Kant, Rajni,Gupta, Vivek K.
, p. 23519 - 23529 (2015/04/14)
O-Cinnamyloxy/geranyloxy/cyclohexenyloxy/cinnamoyloxy-acetophenones yielded pyrazol-heterocycles, all of which contained an angular methyl-attached pyranopyran unit with pyrazolones in the ionic liquid (IL), 1,8-diazabicyclo[5.4.0]undec-7-ene-8-ium acetat
Natural Products as Sources of New Fungicides (I): Synthesis and Antifungal Activity of Acetophenone Derivatives Against Phytopathogenic Fungi
Ma, Ya-Tuan,Fan, Hua-Fang,Gao, Yu-Qi,Li, He,Zhang, An-Ling,Gao, Jin-Ming
, p. 545 - 552 (2013/06/05)
Several series of 45 acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by 1H and 13C NMR spectroscopy, HRMS and single-crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate assay. Of them, 12 derivatives (e.g., 3a-c, 4c and 4e) exhibited more potent antifungal effects on some phytopathogens than a commercial fungicide hymexazol as positive control. In particular, compound 3b with IC50 values of 10-19μg/mL was found to be the most active in this series and might be a potential lead structure for further optimization. The preliminary structure-activity relationship (SAR) studies of a series of acetophenones are also discussed. A series of acetophenone derivatives have been synthesized and tested for their antifungal activities. Of them 12 derivatives exhibited more potent antifungal effects on some phytopathogens than a positive control hymexazol. Especially, compound 3b (IC50=10-19μg/mL) was found to be the most active and might be a potential lead structure. The SAR of these acetophenones is also discussed.
Access to some angular aminochromeno[2,3-c]pyrazole Precursors by a domino knoevenagel-hetero-diels-alder reaction
Parmar, Narsidas J.,Pansuriya, Bhavesh R.,Labana, Balvantsingh M.,Sutariya, Tushar R.,Kant, Rajni,Gupta, Vivek K.
supporting information, p. 5953 - 5964,12 (2020/09/02)
A new, solvent-free tetrabutylammonium-hydrogensulfate-catalysed one-pot procedure to synthesise angular benzopyran-annulated pyrazoles, all of which incorporate a tertiary ring-junction carbon, has been demonstrated. A typical intermediate Knoevenagel he
SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES
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Page/Page column 10-12, (2008/06/13)
The invention relates to substituted hydroxyacetophenon derivatives having antiproliferative and antimicrobial properties, to medicaments containing said derivatives, and to a method for the production thereof. Furthermore, the inventive hydroxyacetopheno
Regioselectivity in the intramolecular allyl transfer reaction catalysed by electrogenerated nickel complexes: Influence of metal ions
Franco, Delphine,Du?ach, Elisabet
, p. 9289 - 9296 (2007/10/03)
The intramolecular transfer of allyl moieties from substituted allyl aryl ethers to carbonyl groups has been studied by electrosynthesis, in a nickel-catalysed reaction. The influence of metal ions such as Mg2+, Zn2+ and Al3+ has been examined. Regioselectivity towards the branched isomer was better with Zn2+ than with Mg2+ ions, but it was higher in the absence of added metal ions.
