7054-58-2

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 459-22-3 4-fluorophenylacetonitrile 
• 105-58-8 Diethyl carbonate 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 32347-96-9 2-(4-fluorophenyl)propanedinitrile 
• 19213-72-0 ethyl 1-imidazolecarboxylate 

Downstream Products

• 91805-85-5 ethyl 2-cyano-2-(4-fluorophenyl)butanoate 
• 927683-87-2 (S)-ethyl 2-(4'-fluorophenyl)-2-cyano-5-oxohexanoate 
• 1151940-45-2 C₁₉H₂₃F₄NO₄S 
• 51632-22-5 2-(4-fluorophenyl)-3-methylbutanenitrile 
• 7054-62-8 dl-1-Brom-2-(4-fluorphenyl)butan 
• 90944-37-9 dl-2-(4-Fluorphenyl)butanol 
• 7139-24-4 4-fluorophenylbutyric acid 
• 133857-60-0 (+/-)-ethyl 2-cyano-2-(4-fluorophenyl)propanoate 

Relevant academic research and scientific papers

FACTOR IXA INHIBITORS

The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, trans

Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles

Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.

THIOAMIDES AND AMIDES FOR CONTROLLING ANIMAL PESTS

The invention relates to the use of a compound of formula (I) or a salt thereof for combating animal pests, where the symbols and indices are defined in the specification.

Metal-free photochemical aromatic perfluoroalkylation of α-cyano arylacetates

We report here an operationally simple protocol for the direct aromatic perfluoroalkylation and trifluoromethylation of α-cyano arylacetates. This metal-free approach, which occurs at ambient temperature and under visible-light irradiation, is driven by t

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.

An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

An efficient method for the synthesis of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC) has been described. Using this method many sterically hindered and highly substituted mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate were synthesized in high yield.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.

METHOD FOR PRODUCING PYRROLIDINE COMPOUND

Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. A method of producing a compound represented by the following formula [8]: or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: or a reactive derivative thereof, or a salt thereof, or a solvate thereof.

Heterocyclic compounds

The present invention provides a compound represented by the following formula [1′] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a