70565-03-6Relevant academic research and scientific papers
Hydrolysis and hydrazinolysis of isatin-based ald-and ketazines
Ibrahim, Hany S.,Abdelhadi, Soha R.,Abdel-Aziz, Hatem A.
, (2015/05/27)
The hydrolysis of isatin aldazine 4a-d afforded the unexpected 3,3'-(hydrazine-1,2-diylidene)bis(indolin-2-one) (5) and 1,2-di(arylidene)hydrazines 6a-d through dual hydrolysis of 4a-d. A mechanism to explain the formation of 5 and 6a-d was proposed. In addition, the hydrazinolysis of 4a-d yielded 3-hydrazonoindolin-2-one (2) and 1,2-di(arylidene)hydrazines 6a-d instead of hydrazones 17a-d, while hydrazinolysis of isatin ketazine 5 gave the expected 3-hydrazonoindolin-2-one (2). These results indicated the ability of the title compounds for unusual hydrolysis and hydrazinolysis reactions.
Synthesis leishmanicidal activities of bis-Schiff bases of isatins
Khan, Momin,Khan, Khalid Mohammed,Rahim, Fazal,Samreen,Perveen, Shahnaz,Karim, Aneela,Imtiazuddin,Choudhary, Muhammad Iqbal
, p. 520 - 526 (2015/08/04)
Twenty seven (27) derivatives of bis-Schiff bases of isatins 1-27 were studied for their leishmanicidal potential. Out of twenty seven (27) analogs, five exhibited varying degree of leishmanicidal activity with IC50 values 44.86 ± 0.66, 65.27 ±
Superoxide respiratory burst inhibitory activity of bis-schiff bases of Isatins
Khan, Khalid Mohammed,Khan, Momin,Ali, Muhammad,Qadir, Muhammad Irfan,Perveen, Shahnaz,Karim, Aneela,Choudhary, Muhammad Iqbal
, p. 987 - 993 (2013/07/26)
Bis-Schiff bases 1-27 were synthesized and evaluated for their anti-inflammatory activity and possible cytotoxicity. Compounds 1-27 showed a varying degree of respiratory burst inhibitory activity with IC50 values between 242.97 - 652.12 μM. Co
Synthesis of bis-Schiff bases of isatins and their antiglycation activity
Khan, Khalid Mohammed,Khan, Momin,Ali, Muhammad,Taha, Muhammad,Rasheed, Saima,Perveen, Shahnaz,Choudhary, M. Iqbal
experimental part, p. 7795 - 7801 (2010/03/30)
Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC50 = 243.95 ± 4.59 μM), 20 (IC50 = 257.61 ± 5.63 μM), and 7 (IC50 = 291.14 ± 2.53 μM) showed an exc
