70570-32-0Relevant articles and documents
Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands
Ghosh, Arun K.,Jadhav, Ravindra D.,Simpson, Hannah,Kovela, Satish,Osswald, Heather,Agniswamy, Johnson,Wang, Yuan-Fang,Hattori, Shin-ichiro,Weber, Irene T.,Mitsuya, Hiroaki
, p. 171 - 182 (2018)
We describe the design, synthesis, and biological evaluation of a series of novel HIV-1 protease inhibitors with carboxamide derivatives as the P2 ligands. We have specifically designed aminothiochromane and aminotetrahydronaphthalene-based carboxamide ligands to promote hydrogen bonding and van der Waals interactions in the active site of HIV-1 protease. Inhibitors 4e and 4j have shown potent enzyme inhibitory and antiviral activity. High resolution X-ray crystal structures of 4d- and 4k-bound HIV-1 protease revealed molecular insights into the ligand-binding site interactions.
