7059-23-6 Usage
Uses
Used in Pharmaceutical Industry:
3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride is used as an anti-cancer agent for its ability to inhibit polyamine synthesis. It has been investigated as a potential treatment for various types of cancer due to its inhibitory effects on the polyamine-biosynthetic pathway, which is often upregulated in cancer cells.
Used in Research Applications:
In the field of research, 3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride is used as a tool compound to study the role of polyamine metabolism in various biological processes, including cancer cell growth and proliferation. It can also be used to investigate the effects of SAMD inhibition on cellular processes and to develop new therapeutic strategies targeting this pathway.
Used in Drug Development:
3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride serves as a lead compound in the development of new drugs targeting the polyamine-biosynthetic pathway. Its unique mechanism of action and potential anti-cancer properties make it an attractive candidate for further optimization and development into more effective and selective inhibitors for cancer treatment.
References
1) Wiliams?et al., (1971),?Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun.,?46?288
2) Corti?et al., (1974),?Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J.,?139?351
3) Williams-Ashman and Seidenfeld, (1986),?Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol.,?35?1217
4) Janne and Morris, (1984),?Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J.,?218?947
5) Pegg?et al., (1985)?Induction of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta,?842?111
6) Porter and Janne (2012)?Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248
Check Digit Verification of cas no
The CAS Registry Mumber 7059-23-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,5 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7059-23:
(6*7)+(5*0)+(4*5)+(3*9)+(2*2)+(1*3)=96
96 % 10 = 6
So 7059-23-6 is a valid CAS Registry Number.
