70591-26-3Relevant articles and documents
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
Beaulieu, Christian,Isabel, Elise,Fortier, Angélique,Massé, Frédéric,Mellon, Christophe,Méthot, Nathalie,Ndao, Momar,Nicoll-Griffith, Deborah,Lee, Doris,Park, Hyeram,Black, W. Cameron
scheme or table, p. 7444 - 7449 (2011/02/23)
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. The identified inhibitors bearing an amino nitrile warhead in P1 exhibit low nanomolar in vitro potency against cruzipain. Further SAR in P2 por