70593-61-2

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloropyridine-2-carboxamide is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs. Its unique structure allows for the creation of a range of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chloropyridine-2-carboxamide serves as an intermediate for the production of various agrochemicals. Its involvement in the synthesis process contributes to the development of compounds that can be used in crop protection and other agricultural applications.
Used in Dye and Pigment Production:
6-Chloropyridine-2-carboxamide is also employed in the manufacturing of dyes and pigments, where its chemical properties contribute to the color and stability of these products.
Safety Note:
It is important to handle 6-Chloropyridine-2-carboxamide with care due to its potential hazards if not used and stored properly, ensuring safety in both industrial and laboratory settings.

InChI:InChI=1/C6H5ClN2O/c7-5-3-1-2-4(9-5)6(8)10/h1-3H,(H2,8,10)

Upstream product

• 629-11-8 1,6-hexanediol 
• 33252-29-8 6-chloro-pyridine-2-carbonitrile 
• 64-17-5 ethanol 
• 109-09-1 2-chloropyridine 
• 2402-95-1 2-chloropyridine-N-oxide 
• 4684-94-0 6-chloropicolinic acid 
• 77287-34-4 formamide 
• 116570-79-7 N-methoxy-2-chloropyridinium methylsulfate 
• 104727-52-8 ethyl 6-chloropyridine-2-carboximidate 

Downstream Products

• 935265-04-6 C₂₂H₂₅N₃O₃ 
• 1012330-19-6 6-(2-(3-(biphenyl-4-yl)-1-(tert-butyldimethylsilyloxy)propyl)oxazol-5-yl)pyridine-2-carboxamide 
• 1012329-92-8 C₂₄H₂₁N₃O₂ 
• 935265-54-6 6-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)picolinamide 

Relevant academic research and scientific papers

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.

A pyridine amide synthetic method of compound

The invention discloses a method for synthesizing a pyridine-amide compound. The method comprises the steps of carrying out hydrolysis on a pyridine cyanogen compound shown by a formula II as a starting material in water as a solvent in the presence of an ETS-10 molecular sieve as a catalyst, heating to 100-150 DEG C, reacting until the reaction, which is tracked and detected by virtue of TLC (Thin-Layer Chromatography), is completed and carrying out post-treatment on the reaction solution to obtain the pyridine-amide compound represented by the formula I. According to the method disclosed by the invention, the ETS-10 molecular sieve is taken as a catalyst to carry out hydrolysis on pyridine cyanogen to obtain a single pyridine-amide product, the conversion rate is 100%, the yield is above 95% and the catalyst can be repeatedly used for at least 5 times.

CXCR4 Receptor Antagonists

Disclosed are compounds that are antagonists of the CXCR4 receptor.

CXCR4 RECEPTOR ANTAGONISTS

The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

SOLVENT AND TEMPERATURE DEPENDENT REGIOSELECTIVE REACTIONS BETWEEN 2-CHLORO-6-CYANOPYRIDINE AND ALIPHATIC ALCOHOLS

Reaction of 2-chloro-6-cyanopyridine with aliphatic mono- and di-alcohols or ethylene glycols affords, depending on the reaction conditions, alkoxypyridines or imino ester pyridines or a mixture of both types of compounds.It is suggested that the product distribution is determined by the stability of an imidate anion formed as an intermediate.An improved synthesis of 2-chloro-6-cyanopyridine is also described.