705941-45-3

Basic information

• Product Name: (4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID
• Synonyms: (4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID;AKOS BB-6746;1-Piperazineaceticacid, 4-acetyl-
• CAS NO: 705941-45-3
• Molecular Formula: C₈H₁₄N₂O₃
• Molecular Weight: 186.21
• Product Categories: Piperaizine;piperazines
• Mol File: 705941-45-3.mol

Chemical Properties

• Boiling Point: 382.4°C at 760 mmHg
• Flash Point: 185.1°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 6.57E-07mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: (4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID(705941-45-3)
• EPA Substance Registry System: (4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID(705941-45-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 705941-45-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID is used as a building block in pharmaceutical research for its potential to contribute to the development of new drugs. Its unique structure and reactivity may allow for the creation of compounds with novel therapeutic effects.
Used in Drug Development:
In the field of drug development, (4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID is utilized as a precursor or intermediate in the synthesis of various pharmaceutical agents, potentially leading to the discovery of new medications with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
(4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID serves as a tool compound in medicinal chemistry, aiding researchers in understanding the biological activity and mechanisms of action of piperazine derivatives, which could be instrumental in the advancement of targeted therapies.
Used in Chemical Synthesis:
(4-ACETYL-PIPERAZIN-1-YL)-ACETIC ACID is used as a reagent in chemical synthesis processes, where its acetyl group may participate in various chemical reactions, facilitating the production of complex organic molecules with specific applications in different industries.

InChI:InChI=1/C8H14N2O3/c1-7(11)10-4-2-9(3-5-10)6-8(12)13/h2-6H2,1H3,(H,12,13)

Upstream product

• 13889-98-0 N-acetylpiperidine 
• 869720-23-0 (4-Acetyl-piperazine-1-yl)-acetic acid methyl ester 
• 156478-71-6 4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazineacetic acid 
• 496808-05-0 2-(piperazin-1-yl)acetic acid 
• 75-36-5 acetyl chloride 

Relevant articles and documents

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1, R2, R4, R5, R6, R7, R8, R9, R10,Z, X1, X2, X3, L2, HET, n and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

NK1 and NK3 antagonists

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-mediated conditions.