705963-56-0

Upstream product

• 558645-43-5 3-(2,4-bis-benzyloxy-5-chlorophenyl)-1H-pyrazole 
• 705963-54-8 1-[2,4-bis(benzyloxy)-5-chlorophenyl]ethan-1-one 
• 95-88-5 4-Chlororesorcinol 
• 90110-32-0 1-(5-chloro-2,4-dihydroxyphenyl)ethan-1-one 

Downstream Products

• 705963-58-2 3-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-bromo-2-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole 
• 705963-57-1 3-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole 

Relevant academic research and scientific papers

3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone

Information from X-ray crystal structures of Hsp90 inhibitors bound to the human Hsp90 molecular chaperone was used to assist in the design of 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel inhibitors of Hsp90. Accessing an extra intera

3-(2-HYDROXY-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS HSP90 INHIBITORS FOR THE TREATMENT OF CANCER

Compounds of formula (IA) or (IB) or salts, N-oxides, hydrates or solvates thereof are Inhibitors of HSP90, and useful in the treatment of, for example, cancer: formula (IA), formula (IB) wherein Ar is an aryl or heteroaryl radical which is linked via a r