70600-02-1Relevant academic research and scientific papers
β-Elimination of the Isonitrile Group in Alkylation Reactions of C-H Acids Activated by the Isonitrile Function
Jawdosiuk, Mikolaj,Uminski, Maciej
, p. 979 - 980 (1982)
During phase-transfer alkylation of the isonitriles R1R2CHNC with X-CH2-Y, where X is a leaving group and Y an electron withdrawing group, some of the alkylation products undergo β-elimination of the isonitrile function to yield R1R2C=CHY.
Compound having dual effects on 5-HT and application thereof in treatment of depression
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Paragraph 0028; 0032; 0033; 0034, (2018/09/21)
The invention discloses a compound having dual effects on 5-HT and application thereof in treatment of depression. As shown in the description, R1, R2, R3 and R4 are independently selected from H, F or CH3. In recent years, a dual-effect anti-depression drug with partial excitation of serotonin 1A receptor and selective serotonin reuptake inhibition becomes a hot spot for new antidepressant research. In rat synaptosome, [3H]5-HT uptake inhibition and h5-HT1A binding affinity experiments prove that the compound has 5-HT reuptake inhibition effect and 5-HT1A receptor excitation effect, indicating that the compound can be used as a medicament for treating central nervous system dysfunction such as depression and anxiety in humans.
Compound having dual functions to 5-HT and application thereof in depressive disorder treatment
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Paragraph 0028; 0032-0031, (2018/10/19)
The invention discloses a compound having dual functions to 5-HT and application thereof in depressive disorder treatment. The formula is shown in the description, wherein R1, R2, R3 and R4 are independently selected from H, F or OH. In recent years, an antidepressant having the dual functions of 5-hydroxytryptamine 1A acceptor partial agitation and selective 5-hydroxytryptamine re-uptake inhibition becomes a hot point direction of a novel antidepressant drug research. In a [3H]5-HT uptake inhibiting effect experiment of a rat synaptosome and a h5-HT1A combined affinity experiment, the compound is verified to have the 5-HT re-uptake inhibiting effect and the agitating effect to a 5-HT1A acceptor. The fact that the compound can be used as a drug for treating human central nervous system disorders, such as a depressive disorder and an anxiety disorder, is demonstrated.
REACTIONS OF ORGANIC ANIONS. PART C. PHASE-TRANSFER ALKYLATION OF C-H ACIDS ACTIVATED BY THE ISONITRILE FUNCTION. UNPRECENDENTED β-ELIMINATION OF THE ISONITRILE GROUP
Jawdosiuk, Mikolaj,Uminski, Maciej,Kmiotek-Skarzynska, Irena,Makasza, Mieczyslaw
, p. 1309 - 1320 (2007/10/02)
Benzylation and nitrobenzylation reactions of isocyanides in a catalytic two-phase system and in some homolytic systems were studied.Elimination of the isocyanide group has been observed in the products obtained.
