70618-53-0Relevant academic research and scientific papers
Manganese(II) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents
Oliveira, Carolina G.,Maia, Pedro Ivo Da S.,Souza, Paula C.,Pavan, Fernando R.,Leite, Clarice Q.F.,Viana, Rommel B.,Batista, Alzir A.,Nascimento, Otaciro R.,Deflon, Victor M.
, p. 21 - 29 (2014/03/21)
Through a systematic variation on the structure of a series of manganese complexes derived from 2-acetylpyridine-N(4)-R-thiosemicarbazones (Hatc-R), structural features have been investigated with the aim of obtaining complexes with potent anti-Mycobacter
Cobalt(III) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents
Oliveira, Carolina G.,Maia, Pedro Ivo Da S.,Miyata, Marcelo,Pavan, Fernando R.,Leite, Clarice Q. F.,De Almeida, Eduardo Tonon,Deflon, Victor M.
, p. 1848 - 1856 (2016/10/12)
CoIII complexes derived from 2-acetylpyridine N(4)-R thiosemicarbazone (Hatc-R, R = alkyl, aryl) have been characterized by elemental analysis, FTIR, UV-Visible and 1H NMR spectroscopies, cyclic voltammetry (CV), conductimetry measur
Synthesis, characterization, and antibacterial activities of organotin(IV) complexes with 2-acetylpyridine-N(4)-cyclohexylthiosemicarbazone (HAPCT)
Salam,Affan,Arafat, Md. Azharul,Saha, Ramkrishna,Nasrin, Runia
, p. 43 - 52 (2013/03/13)
The reaction of 2-acetylpyridine-N(4)-cyclohexylthiosemicarbazone [(HAPCT), (1)] ligand with organotin(IV) chloride(s) afforded the five new organotin(IV) complexes: [MeSnCl2(APCT)] (2), [BuSnCl2(APCT)] (3), [PhSnCl2(APCT)] (4), [Me2SnCl(APCT)] (5), and [Ph 2SnCl(APCT)] (6). The ligand (1) and its organotin(IV) complexes (2-6) have been synthesized and characterized by CHN analyses, molar conductivity, UV-vis, FT IR, 1H, 13C, and 119Sn NMR spectral studies. The single crystal X-ray diffraction studies indicated that [PhSnCl2(APCT)] (4) is six coordinated and strongly adopts a distorted octahedral configuration with the coordination through pyridine-N, azomethine-N, and thiolato-S atoms of the ligand. The compound crystallizes into a monoclinic lattice with the space group P21/n. The ligand (1) and its organotin(IV) complexes (2-6) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, and Salmonella typhi. The screening results have shown that the organotin(IV) complexes (2-6) have better antibacterial activity than the free ligand. Furthermore, it has been shown that the diphenyltin(IV) derivative (6) exhibits significantly better activities than the other organotin(IV) derivatives (2-5).
Synthesis, crystal structures and biological activities of 2-acetylpyridine N(4)-cyclohexylthiosemicarbazone and its manganese(II) and nickel(II) complexes
Li, Ming-Xue,Zhang, Dong,Zhang, Li-Zhi,Niu, Jing-Yang,Ji, Bian-Sheng
experimental part, p. 1572 - 1575 (2011/03/01)
2-Acetylpyridine N(4)-cyclohexylthiosemicarbazone (HL) and its manganese(II) and nickel(II) complexes formulated as [Mn(L)2] (1) and [Ni(L)2] (2) have been synthesized and characterized by elemental analysis, infrared spectra, mass s
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents
Klayman,Bartosevich,Griffin,Mason,Scovill
, p. 855 - 862 (2007/10/04)
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.
