70625-60-4Relevant academic research and scientific papers
Domino synthesis of bridged bicyclic tetrahydro-1,2-oxazines: Access to stereodefined 4-aminocyclohexanols
Dias, Dwayne A.,Kerr, Michael A.
supporting information; experimental part, p. 3694 - 3697 (2011/03/18)
Image Presented The intramolecular variant of the homo-[3 + 2]-dipolar cycloaddition of nitrones (generated in situ from an aldehyde and a hydroxylamine) with donor-acceptor cyclopropanes allows for the efficient synthesis of bridged tetrahydro-1,2-oxazines. This domino sequence produces adducts amenable to reductive N-O bond cleavage producing cis-1,4- aminocyclohexanols in excellent yields.
