70625-84-2Relevant academic research and scientific papers
Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C-H Bonds
Wu, Yunxiang,Zhou, Bing
, p. 2213 - 2217 (2017)
An ideal addition of inert aryl C-H bonds to formaldehyde has been achieved to synthesize a variety of hydroxymethylarenes via a Ru(II)-catalyzed C-H activation. Many different directing groups (not limited to strongly heterocyclic directing groups) can be used, and this challenging C-H hydroxymethylation proceeds in the presence of water and air, without stoichiometric undesirable byproducts, thus offering an environmentally benign method of hydroxymethylarene synthesis that can be readily scaled up.
