70626-04-9

Upstream product

• 42846-54-8 (3-(4-fluorophenyl)oxiran-2-yl)(phenyl)methanone 
• 1483-82-5 phenylethynyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 1765-93-1 4-fluoroboronic acid 
• 211322-72-4 (2E)-2,3-dichloro-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

E - Z isomerization in Suzuki cross-couplings of haloenones: Ligand effects and evidence for a separate catalytic cycle

Suzuki cross-coupling of haloalkenes is generally assumed to occur with retention of the alkene stereochemistry. While studying Suzuki cross-couplings on E-1,2-dichlorovinyl phenyl ketone, we were surprised to observe extensive isomerization. More surprisingly, the ligand employed strongly influenced the degree of isomerization: DPEphos and Xantphos led to 96% isomerized cross-coupled product whereas reactions in the absence of a phosphine ligand, or reactions employing t-BuXantphos, gave 94% retention of stereochemistry. While E-Z isomerization in Pd-catalyzed vinylic couplings has previously been attributed to events within the cross-coupling catalytic cycle, we present experimental and computational evidence for a separate Pd-catalyzed isomerization process in these reactions.

Synthesis method of Z-type halogenated chalcone compound

The invention relates to a synthesis method of a Z-type halogenated chalcone compound as shown in formula (III), characterized by comprising: by using a compound shown in formula (I) and a compound shown in formula (II) as reaction raw materials, using IPrAuCl as a catalyst, using AgSbF as an assistant and using 1,2-dichloroethane as a solvent, performing a reaction at the room temperature; andafter ending the reaction, carrying out post treatment on reaction liquid to obtain the Z-type halogenated chalcone compound as shown in formula (III). The synthesis method disclosed by the inventionis simple and short in step, mild in condition, very high in reaction speed, meanwhile, high in yield and good in regioselectivity, and is a green and economic reaction process; (The formulas are shown in the description.).

An approach to synthesis of (Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)

A series of (Z)-2-chloro-1,3-diarylpropen-l-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-l, 3-diarylpropan-1-ones with Vilsmeier reagent, which was derived from bis(trichloromethyl) carbonate (BTC, triph