1483-82-5

Basic information

• Product Name: 2-chloroethynylbenzene
• Synonyms: 2-chloroethynylbenzene;(Chloroethynyl)benzene;1-Chloro-2-phenylacetylene;1-Chloro-2-phenylethyne;Phenylethynyl chloride
• CAS NO: 1483-82-5
• Molecular Formula: C₈H₅Cl
• Molecular Weight: 136.58
• Mol File: 1483-82-5.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 170.2°C at 760 mmHg
• Flash Point: 70℃
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 1.97mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: ?20°C
• BRN: 1856338
• CAS DataBase Reference: 2-chloroethynylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloroethynylbenzene(1483-82-5)
• EPA Substance Registry System: 2-chloroethynylbenzene(1483-82-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1483-82-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 1487, 1976 DOI: 10.1021/jo00871a001Synthetic Communications, 19, p. 2877, 1989 DOI: 10.1080/00397918908052676

InChI:InChI=1/C8H5Cl/c9-7-6-8-4-2-1-3-5-8/h1-5H

Upstream product

• 624-85-1 ethyl hypochlorite 
• 1004-22-4 (phenylethynyl)sodium 
• 536-74-3 phenylacetylene 
• 6738-06-3 phenylethynylmagnesium bromide 
• 98-09-9 benzenesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 3335-33-9 1-methyl-2-trichloromethyl-benzene 
• 64-19-7 acetic acid 
• 2889-74-9 perchlorate d'acetyle 
• 62847-70-5 4-chloro-3-phenyl-2H-isoxazol-5-one 
• 10165-13-6 1-chloroaziridine 
• 4110-77-4 (E)-β-chlorostyrene 
• 4440-01-1 lithium phenylacetylide 
• 7572-29-4 dichloroethyne 

Downstream Products

• 101-97-3 Ethyl 2-phenylethanoate 
• 75599-98-3 2-Phenyl-1,4,4-trifluoro-3-chloro-2-cyclobutene-1-carboxylic Acid 
• 83188-22-1 2,6,6-trimethyl-2-(phenylethynyl)cyclohexanone 
• 64771-56-8 1,1,3-triphenyl-1-cyanopropyne-2 
• 83188-15-2 2,6-dimethyl-6-(phenylethynyl)-2-cyclohexen-1-one 
• 7608-19-7 P,P-diphenyl-P-phenylethynylphosphane sulphide 
• 16664-50-9 1-phenyl-1-decyne 
• 114143-77-0 2,5-dimethyl-1-(phenylethynyl)-pyrrolidine 
• 501-65-5 diphenyl acetylene 
• 75-00-3 chloroethane 
• 117192-89-9 N,N,N',N'-tetramethyl-P-(phenylethynyl)phosphonothioic diamide 
• 117192-90-2 N,N,N',N'-tetraethyl-P-(phenylethynyl)phosphonothioic diamide 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 58723-96-9 (Z)-1,2-dichloro-2-phenylethylene 

Relevant articles and documents

Analysis of substituent effects on C-13 NMR parameters of substituted arylacetylene derivatives. Linear free energy relationships and PM3 semiempirical calculations

The substituent-induced chemical shifts (SCS) of C(α,β) on the 13C NMR spectra of arylalkynes (i.e. containing H, CH3, Cl and Br) were studied. The correlation between SCS and Hammett constants shows that the tendency of the effect by the substituents on the phenyl ring is Br (ρ=8.15)>Cl (ρ=7.27)>CH3 (ρ=6.79)>H (ρ=5.78). This order can be rationalized as due to the ability of the group on the alkyne to stabilize the partial positive charge on C(β) resulting from polarization with π electron transfer from C(β) to the phenyl ring. The SCS values are also well correlated with the electron densities obtained from PM3 calculations. The solvent effect on the 13C chemical shifts of phenylalkynyl bromide demonstrates a strong dependence on the relative permittivity as well as the shielding character of the solvents. (C) 2000 Elsevier Science Ltd.

Synthesis of new halo-containing acetylenes and their application to the synthesis of azoles

The convenient synthesis of ten halo- and an isoxazole-containing acetylenes from the reaction of acetylenes with n-butyl lithium and subsequent reaction with an electrophile agent (ethyl trichloroacetate, ethyl dichloroacetate, trifluoroacetic anhydride,

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Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks

α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles.

Nickel-Catalyzed Difunctionalization of Alkynyl Bromides with Thiosulfonates and N -Arylthio Succinimides: A Convenient Synthesis of 1,2-Thiosulfonylethenes and 1,1-Dithioethenes

An efficient nickel-catalyzed vicinal thiosulfonylation of 1-bromoalkynes with thiosulfonates in the presence of cesium carbonate is described. An operationally simple and highly regioselective atom transfer radical addition (ATRA) of alkynyl bromides provides a wide range of (E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) in moderate to high yields. The extensive substrate scope of both alkynyl bromides and thiosulfonates is explored with a broad range of functional groups. Indole-derived 1,1-bromoalkenes were also successfully explored in this 1,2-thiosulfonylation process. Moreover, the nickel-catalyzed geminal -dithiolation of alkynyl bromides with N -arylthio succinimides provides 1,1-dithioalkenes in high yields. The present protocol is reliable on gram scale, and a sequential one-pot bromination and thiosulfonylation of phenylacetylene is achieved in a scale-up synthesis. Following control experiments, a plausible mechanism is proposed to rationalize the experimental outcome and the vicinal thio-sulfonylation.

Decatungstate as Direct Hydrogen Atom Transfer Photocatalyst for SOMOphilic Alkynylation

A versatile approach for the alkynylation of a variety of aliphatic hydrogen donors, including alkanes, is reported. We used tetrabutylammonium decatungstate as photocatalyst to generate organoradicals from C-H/Si-H bonds via hydrogen atom transfer. The l