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The chemical compound "6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid" is a complex organic molecule with a molecular formula of C28H31N5O5S. It features a hexanoic acid backbone, with a 1,3-thiazolidine ring attached to the 6th carbon. The 5th position of the thiazolidine ring is substituted with a cyano group, and a 1,6-dihydropyridine moiety is connected to the 4th position. This dihydropyridine contains a methyl group at the 1st position, a 3-methylpiperidinyl group at the 2nd position, and a carbonyl group at the 6th position. The molecule also has a methylidene bridge between the 5th position of the dihydropyridine and the 5th position of the thiazolidine ring. 6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid is known for its potential use in pharmaceutical applications, particularly as a calcium channel blocker, and is often referred to by its common name, Clevidipine.

7063-30-1

7063-30-1 Suppliers

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7063-30-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7063-30-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,6 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7063-30:
(6*7)+(5*0)+(4*6)+(3*3)+(2*3)+(1*0)=81
81 % 10 = 1
So 7063-30-1 is a valid CAS Registry Number.

7063-30-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[5-[[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxopyridin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid

1.2 Other means of identification

Product number -
Other names 2-Methylamino-2-phenyl-cyclohexanon

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7063-30-1 SDS

7063-30-1Relevant academic research and scientific papers

ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS

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Paragraph 0310, (2021/07/02)

Provided herein are arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders.

Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic

Jurásek, Bronislav,Králík, Franti?ek,Rimpelová, Silvie,?ejka, Jan,Setni?ka, Vladimír,Ruml, Tomá?,Kucha?, Martin,Kohout, Michal

, p. 19360 - 19368 (2018/12/13)

In this study, we aim to determine differences in cytotoxicity of racemic deschloroketamine and its enantiomers. The synthesized racemate of this recently rediscovered and abused dissociative anaesthetic was resolved by chiral HPLC and the absolute configuration of the enantiomers was assigned using a combination of circular dichroism methods and single-crystal X-ray. Not only the absolute configuration, but also the most preferred conformers present in the crystal were successfully determined by electron and vibrational circular dichroism supported by ab initio calculations, and confirmed by X-ray. The in vitro cytotoxicity of racemic deschloroketamine and its enantiomers was determined for nine different types of cell lines. Generally, (S)-deschloroketamine exhibited higher cytotoxicity in the majority of cases. For human embryonic kidney cells (HEK 293T), the (S)-enantiomer reached the IC50 below 1 mM concentration and, in consequence, proved to be twice as potent as the (R)-enantiomer. On the other hand, live-cell fluorescence microscopy imaging at sub-IC50 concentrations provided evidence for only a minor effect of deschloroketamine racemate and enantiomers on endoplasmic reticulum stress and mitochondria morphology in neuroblastoma cells SH-SY5Y.

Asymmetric catalysis. Part 153: Metal-catalysed enantioselective α-ketol rearrangement

Brunner, Henri,Kagan, Henri B.,Kreutzer, Georg

, p. 2177 - 2187 (2007/10/03)

Promoted by catalytic amounts of Ni complexes tertiary α-hydroxyketones 1a, 3a-5a undergo rearrangement, forming chiral isomers 1b, 3b-5b. The best enantioselection was obtained with the model system 1-benzoylcyclopentanol 4a/2-hydroxy-2-phenylcyclohexanone 4b. In a ligand screening 2-[4-(S)-tert-butyloxazolin-2-yl]pyridine gave the highest enantiomeric excess of 46% (S)-4b. The analogous isomerisation reactions of α-hydroxyimines 6a, 7a forming chiral α-aminoketones 6b, 7b were established.