70645-37-3

Upstream product

• 139462-58-1 Methyl (R)-5-Iodo-3-isopropenylpentanoate 
• 1343497-59-5 methyl 7-((ethoxycarbonyl)oxy)-6-methyl-2-(phenylsulfonyl)hept-5-enoate 
• 1148131-33-2 2-(phenylsulfonyl)hex-5-enoic acid methyl ester 

Downstream Products

• 139561-18-5 (1S,2S)-2-isopropenyl-1-methylcyclobutanecarboxylic acid 
• 70645-40-8 (2S)-2-Isopropenyl-1-methylcyclobutanecarboxylic acid 
• 113566-18-0 (1S,2S)-2-isopropenyl-1-methylcyclobutanemethyl p-toluenesulfonate 
• 26532-22-9 (1R, 2S)-grandisol 

Relevant academic research and scientific papers

A versatile synthetic approach to grandisol monoterpene pheromone

A versatile and efficient synthetic procedure for the grandisol pheromone library has been established. The key feature of our synthesis involves a versatile and highly regioselective Pd(0)-catalyzed intramolecular allylic alkylation for the key cyclobutane skeleton of grandisol. In this connection, the concise synthesis of (±)-grandisol as well as mechanism study of Pd(0)-catalyzed regioselective cyclization as a key reaction have also been accomplished.

Pheromone Synthesis, CXXXVII. A New Synthesis of (+)-Grandisol

The natural and (+)-enantiomer of grandisol has been synthesized from (R)-(-)-carvone (2) by employing the intramolecular alkylation of 8 to give 9 as the key step. Key words: Anthonomus grandis; oll weevil; carvone; grandisol; pheromones