7065-18-1Relevant academic research and scientific papers
Diphenylarsenic(III) Iodide
Begley, Michael J.,Sowerby, D. Bryan,Silaghi-Dumitrescu, Luminita
, p. 1632 - 1634 (1995)
AsPh2I (iododiphenylarsine) contains arsenic in trigonal pyramidal coordination with iodine and two phenyl groups, with effectively equal As-C distances .Bond angles at arsenic are 101.7 (2) deg between the phenyl groups
α-cationic arsines: Synthesis, structure, reactivity, and applications
Dube, Jonathan W.,Zheng, Yiying,Thiel, Walter,Alcarazo, Manuel
supporting information, p. 6869 - 6877 (2016/06/14)
A series of structurally differentiated cationic arsines containing imidazolium, cyclopropenium, formamidinium, and pyridinium substituents have been synthesized through short and scalable routes. Evaluation of the donor properties of these compounds by IR spectroscopy and DFT calculations reveals similar σ-electron-releasing abilities for all of them; however, their π-acceptor properties are strongly influenced by the nature of the positively charged group. We describe the coordination chemistry of the newly prepared α-cationic arsines toward different metal centers and their reactivity in the presence of strong oxidants to afford cationic As(V) species. Their unique electronic properties have been exploited in Pt(II) catalysis to develop a new catalyst with remarkable activity in the cycloisomerization of enynes to trisubstituted cyclopropanes. To the best of our knowledge, this is the first report on the use of α-cationic arsine ligands in catalysis.
Oral administration of diphenylarsinic acid, a degradation product of chemical warfare agents, induces oxidative and nitrosative stress in cerebellar Purkinje cells
Kato, Koichi,Mizoi, Mutsumi,An, Yan,Nakano, Masayuki,Wanibuchi, Hideki,Endo, Ginji,Endo, Yoko,Hoshino, Mikio,Okada, Shoji,Yamanaka, Kenzo
, p. 1518 - 1525 (2008/03/14)
A new clinical syndrome with prominent cerebellar symptoms in patients living in Kamisu City, Ibaraki Prefecture, Japan, is described. Since the patients ingested drinking water containing diphenylarsinic acid (DPA), a stable degradation product of both diphenylcyanoarsine and diphenylchloroarsine, which were developed for use as chemical weapons and cause severe vomiting and sneezing, DPA was suspected of being responsible for the clinical syndrome. The purpose of the present study was to elucidate prominent cerebellar symptoms due to DPA. The aim of the study was to determine if single (15 mg/kg) or continuous (5 mg/kg/day for 5 weeks) oral administration of DPA to ICR-strain mice induced oxidative and/or nitrosative stress in their brain. Significantly positive staining with malondialdehyde (MDA) and 3-nitrotyrosine (3-NT) was observed in the cerebellar Purkinje cells by repeated administration (5 mg/kg/day) with DPA for 5 weeks that led to the cerebellar symptoms from a behavioral pharmacology standpoint and by single administration of DPA (15 mg/kg). Furthermore, it is possible that the production of 3-NT was not caused by peroxynitrite formation. The present results suggest the possibility that arsenic-associated novel active species may be a factor underlying the oxidative and nitrosative stress in Purkinje cells due to exposure to DPA, and that the damage may lead to the cerebellar symptoms.
Synthesis and characterization of Se-organoarsanyl selenocarboxylates
Kanda,Mizoguchi,Koike,Murai,Kato
, p. 282 - 286 (2007/10/02)
Sodium selenocarboxylates were found to react with organoarsanyl chlorides Ph3-(n)AsCl(n) 1-3 (n = 1, 2, 3) to give the corresponding Se-organoarsanyl esters RCOSeAsPh2 (5), (RCOSe)2AsPh (6) and (RCOSe)3As (7) in good yields. The reaction of Se-diphenylarsanyl 4-methylbenzenecarboselenoate 5g with phenylselenenyl bromide and phenyltellurenyl iodide afforded the corresponding Se-phenyl-selenenyl 13 and Se-phenyltellurenyl esters 14 in moderate yields, while the reaction with sodium phenoxide gave sodium 4- methylbenzenecarboselenoate (4g), phenyl 4-methylbenzoate (11) and phenoxydiphenylarsine (12), indicating the attack of phenoxy anion to both the carbonyl carbon and arsenic atoms.
Chemistry of Polyfunctional Ligands, 60 On Cage Compounds with the Heteroelements Arsenic and Selenium
Ellermann, Jochen,Lietz, Martin
, p. 1514 - 1517 (2007/10/02)
The reaction of 1,1,1-tris(diiodoarsinomethyl)ethane, CH3C(CH2AsI2)3 (1) with NaAs(C6H5)2 in the molar ratio of 1:3 gives 4-methyl-1,2,6-triarsa-tricyclo2,6>-heptane, CH3C(CH2As)3 (2).The previously synthesized CH3C(CH2AsS)3 (4) can be desulphurated with triphenylphosphine to yield also 2.The reaction of 1 with NaSeH gives the new cage compound 6-methyl-1,3,4-triarsa-2,8-diselena-tricyclo3,4>-nonane, CH3C(CH2As)3Se2 (5). - Keywords: Hetero Cage Compounds, Synthesis, Vibrational Spectra, Mass Spectra, 1H NMR Spectra
