70667-26-4 Usage
Description
Omoprostil is a prostaglandin based antiulcer agent structurally related to alprostadil,
enprostil and misoprostol(3). It is reportedly useful in the treatment of gastric ulcer.
Originator
Ono (Japan)
Uses
Ornoprostil is used in immunosuppressive pharmaceutical composition.
Brand name
Alloca; Ronok
Check Digit Verification of cas no
The CAS Registry Mumber 70667-26-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,6,6 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 70667-26:
(7*7)+(6*0)+(5*6)+(4*6)+(3*7)+(2*2)+(1*6)=134
134 % 10 = 4
So 70667-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C23H38O6/c1-4-5-8-16(2)13-18(25)11-12-19-20(22(27)15-21(19)26)14-17(24)9-6-7-10-23(28)29-3/h11-12,16,18-21,25-26H,4-10,13-15H2,1-3H3/b12-11+/t16-,18+,19+,20+,21+/m0/s1
70667-26-4Relevant articles and documents
Synthesis of the key component for preparation of 6-ketoprostaglandins by a two-component coupling process: Synthesis of 6-keto-prostaglandin E1, ornoprostil and Δ2-trans-6-ketoprostaglandin E1
Kawanaka, Yasufumi,Ono, Naoya,Yoshida, Yukio,Okamoto, Sentaro,Sato, Fumie
, p. 715 - 718 (2007/10/03)
Starting with commercially available (3S,4R)-3-(methoxymethyloxy)-2-methylidene-4-siloxycyclopentanone 2, useful 6-keto-prostaglandin intermediates 1 have been prepared in good yields by a sequence of reactions which includes treatment with NaBr in the presence of BF3·OEt2, Pd-catalysed coupling of the resulting 2-bromomethyl-4-siloxycyclopent-2-enone 3 with the alkenylborane 4 or 9 and conversion of the alkenyl moiety into an epoxy and then into a keto group. The synthesis of 6-keto-PGE1, ornoprostil and Δ2-trans-6-keto-PGE1 by using 1 is also described.