70672-05-8Relevant academic research and scientific papers
Fluorogenic ester substrates to assess proteolytic activity
Mugherli, Laurent,Burchak, Olga N.,Chatelain, Francois,Balakirev, Maxim Y.
, p. 4488 - 4491 (2006)
The synthesis of a new type of fluorogenic ester substrates is described. Prepared from fluorescein in three steps with common commercially available precursors, they all generate bright green fluorescence upon proteolysis. Their particular structure allows the same substrate be used to report enzymatic activity of various proteases from serine and cysteine superfamilies. The substrate cleavage is sensitive to specific protease inhibitors providing a tool for inhibitor screening.
Exploiting the higher alkynophilicity of Au-species: Development of a highly selective fluorescent probe for gold ions
Patil, Nitin T.,Shinde, Valmik S.,Thakare, Milind S.,Hemant Kumar,Bangal, Prakriti. R.,Barui, Ayan Kumar,Patra, Chitta Ranjan
, p. 11229 - 11231 (2013/01/15)
A new approach, involving the anchoring-unanchoring of a fluorophore, has been developed for the detection of Au-species. The fluorescent probe was found to be highly selective for sensing gold species in the presence of several other metal ions. A successful application to bioimaging has also been demonstrated with A549 lung cancer cells.
